Organelle-specific bioprobes based on fluorogens with aggregation-induced emission (AIE) characteristics

Fang Hu¹, Bin Liu²

Affiliations

¹ Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. cheliub@nus.edu.sg and Nanoscience and Nanotechnology Institute, National University of Singapore, 2 Engineering Drive 3, Singapore 117581, Singapore.
² Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. cheliub@nus.edu.sg and Institute of Materials Research and Engineering (IMRE), 2 Fusionopolis Way, Innovis, 136834, Singapore.

PMID: 27779629
DOI: 10.1039/c6ob01414c

Review

Organelle-specific bioprobes based on fluorogens with aggregation-induced emission (AIE) characteristics

Fang Hu et al. Org Biomol Chem. 2016.

. 2016 Oct 25;14(42):9931-9944.

doi: 10.1039/c6ob01414c.

Authors

Fang Hu¹, Bin Liu²

Affiliations

¹ Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. cheliub@nus.edu.sg and Nanoscience and Nanotechnology Institute, National University of Singapore, 2 Engineering Drive 3, Singapore 117581, Singapore.
² Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. cheliub@nus.edu.sg and Institute of Materials Research and Engineering (IMRE), 2 Fusionopolis Way, Innovis, 136834, Singapore.

PMID: 27779629
DOI: 10.1039/c6ob01414c

Abstract

Bioprobes based on fluorogens with aggregation-induced emission (AIE) characteristics have been increasingly used in chemosensing and bioimaging due to their high sensitivity, photostability and biocompatibility. In this review, we summarize the design of cellular organelle specific (cytoplasm membrane, mitochondria, lysosomes, lipid droplets and nucleus) AIE bioprobes and their applications in organelle imaging, organelle bioactivity monitoring, and image-guided cancer cell ablation.

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Organelle-specific bioprobes based on fluorogens with aggregation-induced emission (AIE) characteristics

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Organelle-specific bioprobes based on fluorogens with aggregation-induced emission (AIE) characteristics

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