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Comment
. 2016 Oct 24;39(2):131-132.
doi: 10.1016/j.devcel.2016.10.005.

RNA-Seeded Functional Amyloids Balance Growth and Survival

Shawn M Lyons  1 , Paul Anderson  2
Affiliations
Comment

RNA-Seeded Functional Amyloids Balance Growth and Survival

Shawn M Lyons et al. Dev Cell. .

Abstract

In this issue of Developmental Cell, Audas et al. (2016) report non-membrane-enclosed amyloid bodies (ABs) assembled in the nuclei of cells exposed to heat and low pH. Remarkably, ABs form not by liquid-to-liquid phase separation, implicated in RNA-seeded granule assembly, but by an amyloidogenic process that promotes a liquid-to-solid transition.

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Figures

Figure 1
Figure 1. Stress-Induced Ribonucleoprotein Aggregates
A-bodies, described by Audas et al. (2016), are cellular bodies induced by stress and seeded by the expression of non-coding RNAs from the ribosomal RNA loci. Stress granules are sites of stalled translation machinery containing poly(A) mRNA. P-bodies are thought to be sites of mRNA decay because they contain de-adenylated mRNA and are enriched with mRNA decay factors. Nuclear stress granules serve to reprogram gene expression during stress and require the transcription of the satellite III loci.
See this image and copyright information in PMC

Comment on

  • Adaptation to Stressors by Systemic Protein Amyloidogenesis.
    Audas TE, Audas DE, Jacob MD, Ho JJ, Khacho M, Wang M, Perera JK, Gardiner C, Bennett CA, Head T, Kryvenko ON, Jorda M, Daunert S, Malhotra A, Trinkle-Mulcahy L, Gonzalgo ML, Lee S. Audas TE, et al. Dev Cell. 2016 Oct 24;39(2):155-168. doi: 10.1016/j.devcel.2016.09.002. Epub 2016 Oct 6. Dev Cell. 2016. PMID: 27720612 Free PMC article.

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