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Comment
. 2016 Oct 24;26(20):R932-R934.
doi: 10.1016/j.cub.2016.08.052.

Axonal Degeneration: RIPK1 Multitasking in ALS

Kristin Politi  1 , Serge Przedborski  2
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Axonal Degeneration: RIPK1 Multitasking in ALS

Kristin Politi et al. Curr Biol. .
Free article

Abstract

A recent study reports that microglia and oligodendrocytes promote motor neuron degeneration by inducing inflammation and necroptosis in a manner dependent on receptor-interacting kinase 1 (RIPK1). These findings could be significant for our understanding of the neurobiology and treatment of neurodegenerative diseases like amyotrophic lateral sclerosis.

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