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Editorial
. 2016 Oct 5;2(4):227-231.
doi: 10.1016/S2055-6640(20)30875-X.

Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia

Bui Vu Huy  1 , Sirinya Teeraananchai  2 , Le Ngoc Oanh  3 , John Tucker  4 , Nia Kurniati  5 , Rawiwan Hansudewechakul  6 , Khanh Huu Truong  7 , Vohith Khol  8 , Lam Van Nguyen  9 , Viet Chau Do  10 , Pagakrong Lumbiganon  11 , Nantaka Kongstan  12 , Torsak Bunupuradah  2 , Tavitiya Sudjaritruk  13 , Nagalingeswaran Kumarasamy  14 , Nik Khairulddin Nik Yusoff  15 , Kamarul Azahar Mohd Razali  16 , Dewi Kumara Wati  17 , Moy Siew Fong  18 , Revathy Nallusamy  19 , Azar Kariminia  20 , Annette H Sohn  21
Affiliations
Editorial

Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia

Bui Vu Huy et al. J Virus Erad. .

Abstract

An analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 years) and 1058 (25%) were double orphans (7 years). Ten-year post-ART survival was 93.4-95.2% across orphan categories. Clinic transfers were higher among single and double orphans than non-orphans (41% vs 11%, P<0.001). On multivariate analysis, children ≥3 years at ART initiation (hazard ratio 1.58 vs <3 years, 95% confidence interval: 1.11-2.24) were more likely to be lost to follow-up. Although post-ART mortality and retention did not differ by orphan status, orphans were at greater risk of starting ART at older ages, and with more severe immunosuppression and poorer growth.

Keywords: Asia; HIV; antiretroviral; orphan; paediatric; treatment.

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