Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA

Jeymohan Joseph¹, Paola Cinque², Deborah Colosi¹, Ameet Dravid³, Luminita Ene⁴, Howard Fox⁵, Dana Gabuzda⁶, Magnus Gisslen⁷, Sarah Beth Joseph⁸, Scott Letendre⁹, Shibani S Mukerji¹⁰, Avindra Nath¹¹, Ignacio Perez-Valero¹², Deborah Persaud¹³, Richard W Price¹⁴, Vasudev R Rao¹, Ned Sacktor¹⁵, Ronald Swanstrom⁸, Alan Winston¹⁶, Valerie Wojna¹⁷, Edwina Wright¹⁸, Serena Spudich¹⁹

Affiliations

¹ Division of AIDS Research , National Institute of Mental Health, National Institutes of Health , Bethesda , MD , USA.
² Department of Infectious Diseases , IRCCS San Raffaele Scientific Institute , Milan , Italy.
³ Department of HIV Medicine , Ruby Hall Clinic , Pune , India.
⁴ Department of Infectious Diseases , 'Dr Victor Babes' Hospital for Infectious and Tropical Diseases , Bucharest , Romania.
⁵ Department of Pharmacology and Experimental Neuroscience , University of Nebraska Medical Center , Omaha , NE , USA.
⁶ Department of Cancer Immunology and Virology , Dana-Farber Cancer Institute , Boston , MA , USA.
⁷ Department of Infectious Diseases , Sahlgrenska Academy , University of Gothenburg , Gothenburg , Sweden.
⁸ Department of Microbiology and Immunology , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA .
⁹ Department of Medicine , University of California , San Diego , CA , USA.
¹⁰ Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
¹¹ Section of Infections of the Nervous System , National Institute of Neurological Diseases and Stroke , National Institutes of Health , Bethesda , MD , USA.
¹² Department of Internal Medicine - HIV Unit , Hospital La Paz-IdiPAZ , Madrid , Spain .
¹³ Johns Hopkins University School of Medicine & Bloomberg School of Public Health , Baltimore , MD , USA.
¹⁴ Department of Neurology , University of California , San Francisco , CA , USA.
¹⁵ Department of Neurology , Johns Hopkins University , Baltimore , MD , USA.
¹⁶ Division of Infectious Diseases , Imperial College London , London , UK.
¹⁷ Division of Neurology , University of Puerto Rico-Medical Sciences Campus , San Juan , PR , USA.
¹⁸ Department of Infectious Diseases , Alfred Health , Melbourne , Australia.
¹⁹ Department of Neurology , Yale University , New Haven , CT , USA.

PMID: 27781109
PMCID: PMC5075354
DOI: 10.1016/S2055-6640(20)30879-7

Editorial

Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA

Jeymohan Joseph et al. J Virus Erad. 2016.

. 2016 Oct 5;2(4):243-250.

doi: 10.1016/S2055-6640(20)30879-7.

Authors

Affiliations

¹ Division of AIDS Research , National Institute of Mental Health, National Institutes of Health , Bethesda , MD , USA.
² Department of Infectious Diseases , IRCCS San Raffaele Scientific Institute , Milan , Italy.
³ Department of HIV Medicine , Ruby Hall Clinic , Pune , India.
⁴ Department of Infectious Diseases , 'Dr Victor Babes' Hospital for Infectious and Tropical Diseases , Bucharest , Romania.
⁵ Department of Pharmacology and Experimental Neuroscience , University of Nebraska Medical Center , Omaha , NE , USA.
⁶ Department of Cancer Immunology and Virology , Dana-Farber Cancer Institute , Boston , MA , USA.
⁷ Department of Infectious Diseases , Sahlgrenska Academy , University of Gothenburg , Gothenburg , Sweden.
⁸ Department of Microbiology and Immunology , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA .
⁹ Department of Medicine , University of California , San Diego , CA , USA.
¹⁰ Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
¹¹ Section of Infections of the Nervous System , National Institute of Neurological Diseases and Stroke , National Institutes of Health , Bethesda , MD , USA.
¹² Department of Internal Medicine - HIV Unit , Hospital La Paz-IdiPAZ , Madrid , Spain .
¹³ Johns Hopkins University School of Medicine & Bloomberg School of Public Health , Baltimore , MD , USA.
¹⁴ Department of Neurology , University of California , San Francisco , CA , USA.
¹⁵ Department of Neurology , Johns Hopkins University , Baltimore , MD , USA.
¹⁶ Division of Infectious Diseases , Imperial College London , London , UK.
¹⁷ Division of Neurology , University of Puerto Rico-Medical Sciences Campus , San Juan , PR , USA.
¹⁸ Department of Infectious Diseases , Alfred Health , Melbourne , Australia.
¹⁹ Department of Neurology , Yale University , New Haven , CT , USA.

PMID: 27781109
PMCID: PMC5075354
DOI: 10.1016/S2055-6640(20)30879-7

Abstract

CSF HIV escape is a recently recognised phenomenon that suggests that despite suppressive treatment, HIV RNA may be detected in the CNS compartment in some individuals. In rare cases this is associated with clinical neurological disease, while in most cases, neurological consequences are not apparent. Attempts at characterising the biological substrates of CSF escape and further investigating the neurological consequences need to be made to better understand the implications of this condition for the HIV cure agenda as well as for clinical outcomes. The Global CSF HIV-1 Escape Consortium meeting, convened by the US National Institute of Mental Health, was a first step to gather investigators from diverse sites to discuss opportunities for future collaborative work on this emerging issue. To better understand CSF HIV escape and allow cross-site data reconciliation, it will be useful to reach a consensus set of definitions of the distinct forms of CSF escape, without which concerted cross-site efforts are difficult.

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Figures

**Figure 1.**
Geograhic distribution of cohorts presented at the Global HIV-1 CSF Escape Meeting

See this image and copyright information in PMC

References

1. Deeks SG, Lewin SR, Ross AL et al. . International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat Med 2016; 22: 839– 850. - PMC - PubMed
1. Eden A, Fuchs D, Hagberg L et al. . HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment. J Infect Dis 2010; 202: 1819– 1825. - PMC - PubMed
1. Dravid AN, Kulkarni MV, Mahajan U et al. . Cerebrospinal fluid (CSF) HIV escape is associated with progressive neurologic deterioration in patients on virologically suppressive antiretroviral therapy(ART) in Western India. European AIDS Conference. October 2015. Barcelona, Spain.
1. Cserhati MF, Pandey S, Beaudoin JJ et al. . The National NeuroAIDS Tissue Consortium (NNTC) Database: an integrated database for HIV-related studies. Database (Oxford) 2015; 2015: bav074. - PMC - PubMed
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Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA

Affiliations

Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA

Authors

Affiliations

Abstract

Figures

References

Publication types

Grants and funding

LinkOut - more resources

Full Text Sources