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. 2016 Oct 24;21(10):1402.
doi: 10.3390/molecules21101402.

Naturally Occurring Cinnamic Acid Sugar Ester Derivatives

Yuxin Tian  1 , Weirui Liu  2 , Yi Lu  3 , Yan Wang  4 , Xiaoyi Chen  5 , Shaojuan Bai  6 , Yicheng Zhao  7 , Ting He  8 , Fengxue Lao  9 , Yinghui Shang  10 , Yu Guo  11 , Gaimei She  12
Affiliations

Naturally Occurring Cinnamic Acid Sugar Ester Derivatives

Yuxin Tian et al. Molecules. .

Abstract

Cinnamic acid sugar ester derivatives (CASEDs) are a class of natural product with one or several phenylacrylic moieties linked with the non-anomeric carbon of a glycosyl skeleton part through ester bonds. Their notable anti-depressant and brains protective activities have made them a topic of great interest over the past several decades. In particular the compound 3',6-disinapoylsucrose, the index component of Yuanzhi (a well-known Traditional Chinese Medicine or TCM), presents antidepressant effects at a molecular level, and has become a hotspot of research on new lead drug compounds. Several other similar cinnamic acid sugar ester derivatives are reported in traditional medicine as compounds to calm the nerves and display anti-depression and neuroprotective activity. Interestingly, more than one third of CASEDs are distributed in the family Polygalaceae. This overview discusses the isolation of cinnamic acid sugar ester derivatives from plants, together with a systematic discussion of their distribution, chemical structures and properties and pharmacological activities, with the hope of providing references for natural product researchers and draw attention to these interesting compounds.

Keywords: cinnamic acid sugar ester derivatives; pharmacological activity; phytochemistry; traditional Chinese medicine.

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Conflict of interest statement

The authors declare no conflict ofinterest.

Figures

Figure 1
Figure 1
Substituent groups.
Figure 2
Figure 2
Structures of compounds 1–10.
Figure 3
Figure 3
Structures of compounds 11–15.
Figure 4
Figure 4
Structures of compounds 16–20.
Figure 5
Figure 5
Structures of compounds 21–27.
Figure 6
Figure 6
Structures of compounds 28–120.
Figure 7
Figure 7
Structure of compound 121.
Figure 8
Figure 8
Structures of compounds 122–140.
Figure 9
Figure 9
Structure of compound 141.
Figure 10
Figure 10
Structures of compounds 142–143.
Figure 11
Figure 11
Structure of compound 144.
Figure 12
Figure 12
Structures of compounds 145–147.
Figure 13
Figure 13
Structure of compound 148.
Figure 14
Figure 14
Structure of compound 149.
Figure 15
Figure 15
Structures of compounds 150–155.
Figure 16
Figure 16
Structures of compounds 156–162.
Figure 17
Figure 17
Structures of compounds 163–166.
Figure 18
Figure 18
Structures of compounds 167–168.
Figure 19
Figure 19
Structures of compounds 169–172.
Figure 20
Figure 20
Structures of compounds 173–174.
Figure 21
Figure 21
Structure of compound 175.
Figure 22
Figure 22
Structures of compounds 176–177.
Figure 23
Figure 23
Structure of compound 178.
Figure 24
Figure 24
Structures of compounds 179–182.
Figure 25
Figure 25
Structures of compounds 183–187.
Figure 26
Figure 26
Structures of compounds 188–192.
Figure 27
Figure 27
Structure of compound 193.
Figure 28
Figure 28
Structures of compounds 194–195.
Figure 29
Figure 29
Structure of compound 196.
Figure 30
Figure 30
Structures of compounds 197–201.
Figure 31
Figure 31
Structures of compounds 202–205.
Figure 32
Figure 32
Structures of compounds 206–207.
Figure 33
Figure 33
Structures of compounds 208–213.
Figure 34
Figure 34
Structures of compounds 214–216.
Figure 35
Figure 35
Structures of compounds 217–218.
Figure 36
Figure 36
Structure of compound 219.
Figure 37
Figure 37
Structure of compound 220.
Figure 38
Figure 38
Structures of compounds 221–223.
Figure 39
Figure 39
Structure of compound 224.
Figure 40
Figure 40
Structures of compounds 225–227.
Figure 41
Figure 41
Structure of compound 228.
Figure 42
Figure 42
Structure of compound 229.
Figure 43
Figure 43
Structure of compound 230.
Figure 44
Figure 44
Structures of compounds 231–232.
Figure 45
Figure 45
Structures of compounds 233–234.
Figure 46
Figure 46
Structures of compounds 235–238.
Figure 47
Figure 47
Structures of compounds 239–240.
Figure 48
Figure 48
Structures of compounds 241–242.
Figure 49
Figure 49
Structure of compound 243.
Figure 50
Figure 50
Structure of compound 244.
Figure 51
Figure 51
Structure of compound 245.
Figure 52
Figure 52
Structure of compound 246.
Figure 53
Figure 53
Structures of compounds 247–248.
Figure 54
Figure 54
Structures of compounds 249–254.
Figure 55
Figure 55
Structures of compounds 255–260.
Figure 56
Figure 56
Structure of compound 261.
Figure 57
Figure 57
Structures of compounds 262–274.
Figure 58
Figure 58
Structure of compound 275.
Figure 59
Figure 59
Structure of compound 276.
Figure 60
Figure 60
Structures of compounds 277–279.
Figure 61
Figure 61
Structures of compounds 280–294.
Figure 62
Figure 62
Structures of compounds 295–305.
Figure 63
Figure 63
Structures of compounds 306–316.
Figure 64
Figure 64
Structures of compounds 317–320.
Figure 65
Figure 65
Structures of compounds 321–322.
Figure 66
Figure 66
Structures of compounds 323–324.
Figure 67
Figure 67
Structures of compounds 325–328.
Figure 68
Figure 68
Structure of compound 329.
Figure 69
Figure 69
Structure of compound 330.
Figure 70
Figure 70
Structures of compounds 331–332.
Figure 71
Figure 71
Structure of compound 333.
Figure 72
Figure 72
Structure of compound 334.
See this image and copyright information in PMC

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