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Comment
. 2016 Oct 25;316(16):1708-1709.
doi: 10.1001/jama.2016.12399.

Interventions for Vitiligo

Khaled Ezzedine  1 , Maxine Whitton  2 , Mariona Pinart  3
Affiliations
Comment

Interventions for Vitiligo

Khaled Ezzedine et al. JAMA. .

Abstract

Clinical question: Which interventions are associated with highest efficacy and fewest adverse events for treating vitiligo?

Bottom line: Combination therapies, particularly those involving some form of light (ie, narrowband UV-B) were associated with more improved repigmentation than monotherapies. There was limited evidence to support the association of UV-A alone and UV-B alone with repigmentation for vitiligo. There was moderate evidence to support the association of UV-A and UV-B, when used in combination with psoralens, topical corticosteroids, vitamin D analogues, fluorouracil, azathioprine, and oral prednisolone with improved outcomes for vitiligo. However, combination therapies were associated with more adverse effects.

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  • Interventions for vitiligo.
    Whitton ME, Pinart M, Batchelor J, Leonardi-Bee J, González U, Jiyad Z, Eleftheriadou V, Ezzedine K. Whitton ME, et al. Cochrane Database Syst Rev. 2015 Feb 24;2015(2):CD003263. doi: 10.1002/14651858.CD003263.pub5. Cochrane Database Syst Rev. 2015. PMID: 25710794 Free PMC article.

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