Not all β-lactams are equal regarding neurotoxicity

Khalil Chaïbi¹, Maïté Chaussard^{1

2}, Sabri Soussi^{1

2}, Matthieu Lafaurie³, Matthieu Legrand^{4

5

6}

Affiliations

¹ Department of Anesthesiology and Critical Care and Burn Unit, St-Louis Hospital, Assistance Publique- Hopitaux de Paris, Paris, France.
² University Paris Diderot, Paris, France.
³ AP-HP, Infectious disease, St-Louis Hospital, Paris, France.
⁴ Department of Anesthesiology and Critical Care and Burn Unit, St-Louis Hospital, Assistance Publique- Hopitaux de Paris, Paris, France. matthieu.legrand@aphp.fr.
⁵ University Paris Diderot, Paris, France. matthieu.legrand@aphp.fr.
⁶ UMR INSERM 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital University Paris Diderot, F-75475, Paris, France. matthieu.legrand@aphp.fr.

Comment

Khalil Chaïbi et al. Crit Care. 2016.

. 2016 Oct 27;20(1):350.

doi: 10.1186/s13054-016-1522-z.

Khalil Chaïbi¹, Maïté Chaussard^{1

2}, Sabri Soussi^{1

2}, Matthieu Lafaurie³, Matthieu Legrand^{4

5

6}

¹ Department of Anesthesiology and Critical Care and Burn Unit, St-Louis Hospital, Assistance Publique- Hopitaux de Paris, Paris, France.
² University Paris Diderot, Paris, France.
³ AP-HP, Infectious disease, St-Louis Hospital, Paris, France.
⁴ Department of Anesthesiology and Critical Care and Burn Unit, St-Louis Hospital, Assistance Publique- Hopitaux de Paris, Paris, France. matthieu.legrand@aphp.fr.
⁵ University Paris Diderot, Paris, France. matthieu.legrand@aphp.fr.
⁶ UMR INSERM 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital University Paris Diderot, F-75475, Paris, France. matthieu.legrand@aphp.fr.

No abstract available

Comment on

Absence of obvious link between supra-therapeutic serum levels of β lactams and clinical toxicity in ICU patients with acute renal failure treated with intermittent hemodialysis.
May F, El-Helali N, Timsit JF, Misset B. May F, et al. Crit Care. 2016 Aug 1;20(1):220. doi: 10.1186/s13054-016-1394-2. Crit Care. 2016. PMID: 27476556 Free PMC article. No abstract available.

1. May F, El-Helali N, Timsit J-F, Misset B. Absence of obvious link between supra-therapeutic serum levels of β lactams and clinical toxicity in ICU patients with acute renal failure treated with intermittent hemodialysis. Crit Care. 2016;20:220. doi: 10.1186/s13054-016-1394-2. - DOI - PMC - PubMed
1. Honore PM, Spapen HD. Cefepime-induced neurotoxicity in critically ill patients undergoing continuous renal replacement therapy: beware of dose reduction! Crit Care. 2015;19:455. doi: 10.1186/s13054-015-1179-z. - DOI - PMC - PubMed
1. Chapuis TM, Giannoni E, Majcherczyk PA, Chioléro R, Schaller M-D, Berger MM, et al. Prospective monitoring of cefepime in intensive care unit adult patients. Crit Care. 2010;14:R51. doi: 10.1186/cc8941. - DOI - PMC - PubMed
1. Sutter R, Rüegg S, Tschudin-Sutter S. Seizures as adverse events of antibiotic drugs: a systematic review. Neurology. 2015;85:1332–1341. doi: 10.1212/WNL.0000000000002023. - DOI - PubMed
1. Fugate JE, Kalimullah EA, Hocker SE, Clark SL, Wijdicks EFM, Rabinstein AA. Cefepime neurotoxicity in the intensive care unit: a cause of severe, underappreciated encephalopathy. Crit Care. 2013;17:R264. doi: 10.1186/cc13094. - DOI - PMC - PubMed