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Review
. 2017 Feb;137(2):288-294.
doi: 10.1016/j.jid.2016.08.013. Epub 2016 Oct 23.

Emerging Skin T-Cell Functions in Response to Environmental Insults

Jutamas Suwanpradid  1 , Zachary E Holcomb  2 , Amanda S MacLeod  3
Affiliations
Review

Emerging Skin T-Cell Functions in Response to Environmental Insults

Jutamas Suwanpradid et al. J Invest Dermatol. 2017 Feb.

Abstract

Skin is the primary barrier between the body and the outside world, functioning not only as a physical barrier, but also as an immunologic first line of defense. A large number of T cells populate the skin. This review highlights the ability of these cutaneous T cells to regulate skin-specific environmental threats, including microbes, injuries, solar UV radiation, and allergens. Since much of this knowledge has been advanced from murine studies, we focus our review on how the mouse state has informed the human state, emphasizing the key parallels and differences.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors state no conflict of interest.

Figures

Figure 1
Figure 1. Murine and human skin harbors T cells
The illustration of diverse cutaneous T cell populations in the human and mouse. DETC, dendritic epidermal T cell; TRM, tissue-resident memory T cell.
See this image and copyright information in PMC

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