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Review
. 2016 Oct 27;18(11):1122-1124.
doi: 10.1038/ncb3435.

Targeting mutant p53 through the mevalonate pathway

William Freed-Pastor  1 , Carol Prives  2
Affiliations
Review

Targeting mutant p53 through the mevalonate pathway

William Freed-Pastor et al. Nat Cell Biol. .

Abstract

It is well established that mutant forms of the p53 tumour suppressor acquire pro-oncogenic activities. Inhibition of the mevalonate pathway is now shown to promote degradation of select oncogenic mutant p53 proteins, indicating that destabilization of mutant p53 could be a promising therapeutic strategy.

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References

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