Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Oct;95(43):e5156.
doi: 10.1097/MD.0000000000005156.

Does CYP2E1 RsaI/PstI polymorphism confer head and neck carcinoma susceptibility?: A meta-analysis based on 43 studies

Xianlu Zhuo  1 , Jue Song, Jian Liao, Wei Zhou, Huiping Ye, Qi Li, Zhaolan Xiang, Xueyuan Zhang
Affiliations
Review

Does CYP2E1 RsaI/PstI polymorphism confer head and neck carcinoma susceptibility?: A meta-analysis based on 43 studies

Xianlu Zhuo et al. Medicine (Baltimore). 2016 Oct.

Abstract

Background: Previous reports showed that CYP2E1 RsaI/PstI polymorphism may be a risk factor for cancers. Published meta-analyses in 2010 and 2011, respectively, on the relationship of CYP2E1 RsaI/PstI polymorphisms with the susceptibility to head and neck carcinoma (HNC) have generated inconsistent results. Thus, this study aimed to conduct an updated meta-analysis involving published studies up to Nov 2015 to get a more confidential result.

Methods: Eligible studies up to Nov 2015 were retrieved and screened. Data were extracted and a quantitative meta-analysis was conducted. Subgroup analyses on ethnicity, source of controls, sample size, genotyping method, smoking status, and drinking status were also performed.

Results: Forty-one publications including a total of 43 case-control studies were selected for analysis. The overall data under a homozygote comparison model indicated a significant association of CYP2E1 RsaI/PstI polymorphisms with HNC risk (c2c2 vs c1c1: odds ratio [OR] = 1.97; 95% confidence interval [CI] = 1.53-2.53). Similar results were observed in the Asian subgroup (c2c2 vs c1c1: OR = 1.98; 95%CI = 1.51-2.60; c2 vs c1: OR = 1.20; 95%CI = 1.03-1.39) and mixed population (c2 vs c1: OR = 1.41; 95%CI = 1.06-1.86) when the data were stratified by ethnicities. Interestingly, increased cancer risk only was shown among never-smokers (c2c2+c1c2 vs c1c1: OR = 1.44; 95%CI = 1.05-1.98) but not ever-smokers.

Conclusion: CYP2E1 RsaI/PstI polymorphisms may modify the susceptibility to HNC, particularly among Asians, mixed population, and never-smokers. Future large and well-designed studies are needed to verify this conclusion.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
The flow diagram of included/excluded studies.
Figure 2
Figure 2
Meta-analysis for the association of HNC risk with CYP2E1 RsaI/PstI polymorphism for the overall data (c2c2+c1c2 vs c1c1). HNC = head and neck cancer.
Figure 3
Figure 3
Meta-analysis for the association of HNC risk with CYP2E1 RsaI/PstI polymorphism (c2 vs c1; stratified by ethnicity). HNC = head and neck cancer.
Figure 4
Figure 4
Meta-analysis for the association of HNC risk with CYP2E1 RsaI/PstI polymorphism (c2c2+c1c2 vs c1c1; stratified by smoking status). HNC = head and neck cancer.
Figure 5
Figure 5
Publication bias test for the overall data (c2c2+c1c2 vs c1c1): (A) funnel plot; (B) Egger's linear regression test.
See this image and copyright information in PMC

References

    1. Specenier P, Vermorken JB. Cetuximab: its unique place in head and neck cancer treatment. Biologics 2013; 7:77–90. - PMC - PubMed
    1. Toporcov TN, Znaor A, Zhang ZF, et al. Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium. Int J Epidemiol 2015; 44:169–185. - PMC - PubMed
    1. Field N, Lechner M. Exploring the implications of HPV infection for head and neck cancer. Sex Transm Infect 2015; 91:229–230. - PMC - PubMed
    1. Little MA, Pokhrel P, Murphy KL, et al. The reasons for betel-quid chewing scale: assessment of factor structure, reliability, and validity. BMC Oral Health 2014; 14:62. - PMC - PubMed
    1. Choudhury JH, Ghosh SK. Gene-environment interaction and susceptibility in head and neck cancer patients and in their first-degree relatives: a study of Northeast Indian population. J Oral Pathol Med 2015; 44:495–501. - PubMed

MeSH terms