The gut microbiome-an emerging complex trait
- PMID: 27787511
- DOI: 10.1038/ng.3707
The gut microbiome-an emerging complex trait
Abstract
As the first series of genetic analyses of gut microbiome composition in humans is now emerging, the results should be met with enthusiasm, but also with caution. Findings from the initial offerings demonstrate how population-scale approaches can provide deeper insights into host-microbiome interactions while at the same time illustrating that our understanding of the architecture of highly complex microbiome 'traits' is still rudimentary.
Similar articles
-
Host Genetics and Gut Microbiome: Challenges and Perspectives.Trends Immunol. 2017 Sep;38(9):633-647. doi: 10.1016/j.it.2017.06.003. Epub 2017 Jun 29. Trends Immunol. 2017. PMID: 28669638 Review.
-
Sex-Specific Effects of Arsenic Exposure on the Trajectory and Function of the Gut Microbiome.Chem Res Toxicol. 2016 Jun 20;29(6):949-51. doi: 10.1021/acs.chemrestox.6b00066. Epub 2016 Jun 9. Chem Res Toxicol. 2016. PMID: 27268458 Free PMC article.
-
Microbes and the mind: emerging hallmarks of the gut microbiota-brain axis.Cell Microbiol. 2016 May;18(5):632-44. doi: 10.1111/cmi.12585. Epub 2016 Mar 31. Cell Microbiol. 2016. PMID: 26918908 Review.
-
Human Gut Microbiome: Function Matters.Trends Microbiol. 2018 Jul;26(7):563-574. doi: 10.1016/j.tim.2017.11.002. Epub 2017 Nov 22. Trends Microbiol. 2018. PMID: 29173869 Review.
-
Gut microbiome in health and disease: Linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases.Pharmacol Ther. 2016 Feb;158:52-62. doi: 10.1016/j.pharmthera.2015.11.012. Epub 2015 Nov 26. Pharmacol Ther. 2016. PMID: 26627987 Free PMC article. Review.
Cited by
-
Mind the gut: genomic insights to population divergence and gut microbial composition of two marine keystone species.Microbiome. 2018 May 2;6(1):82. doi: 10.1186/s40168-018-0467-7. Microbiome. 2018. PMID: 29720271 Free PMC article.
-
Functional Genomics of Host-Microbiome Interactions in Humans.Trends Genet. 2018 Jan;34(1):30-40. doi: 10.1016/j.tig.2017.10.001. Epub 2017 Oct 26. Trends Genet. 2018. PMID: 29107345 Free PMC article. Review.
-
MiMeNet: Exploring microbiome-metabolome relationships using neural networks.PLoS Comput Biol. 2021 May 17;17(5):e1009021. doi: 10.1371/journal.pcbi.1009021. eCollection 2021 May. PLoS Comput Biol. 2021. PMID: 33999922 Free PMC article.
-
C-Type Lectin Receptors-Triggered Antifungal Immunity May Synergize with and Optimize the Effects of Immunotherapy in Hepatocellular Carcinoma.J Inflamm Res. 2023 Jan 5;16:19-33. doi: 10.2147/JIR.S394503. eCollection 2023. J Inflamm Res. 2023. PMID: 36636249 Free PMC article.
-
Heritable Bovine Rumen Bacteria Are Phylogenetically Related and Correlated with the Cow's Capacity To Harvest Energy from Its Feed.mBio. 2017 Aug 15;8(4):e00703-17. doi: 10.1128/mBio.00703-17. mBio. 2017. PMID: 28811339 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous