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Review
. 2017 Jul;23(3):463-470.
doi: 10.1007/s12253-016-0137-7. Epub 2016 Oct 27.

The Role of IL-37 in Non-Cancerous Diseases

Vivi A Ding  1 , Ziwen Zhu  2 , Alyse A Mantz  1 , Huaping Xiao  3 , Mark R Wakefield  2 , Qian Bai  2 , Yujiang Fang  4   5
Affiliations
Free article
Review

The Role of IL-37 in Non-Cancerous Diseases

Vivi A Ding et al. Pathol Oncol Res. 2017 Jul.
Free article

Abstract

IL-37 is a newly discovered cytokine belonging to IL-1 family consisting of 11 members, which have similar β-barrel structures and associate with Ig-like receptors. Extensive studies have been done with IL-37 since its discovery. These studies suggest that IL-37 does not only play a role in tumorigenesis, but also has anti-inflammatory properties in immune responses through the down regulation of pro-inflammatory molecules. We have previously reviewed the role of IL-37 in cancer. Here, we will focus on the role of IL-37 in non-cancerous Diseases. Such a study might be helpful to design new strategies to treat IL-37 associated diseases.

Keywords: IL-37; Non-cancerous diseases.

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