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Review
. 2016 Nov;27(4):893-908.
doi: 10.1016/j.pmr.2016.06.003.

Autologous Conditioned Serum

Christopher H Evans  1 , Xavier Chevalier  2 , Peter Wehling  3
Affiliations
Review

Autologous Conditioned Serum

Christopher H Evans et al. Phys Med Rehabil Clin N Am. 2016 Nov.

Abstract

Autologous conditioned serum was developed in the mid 1990s as an expeditious, practical, and relatively inexpensive means of generating the interleukin-1 receptor antagonist, a naturally occurring inhibitor of the cytokine interleukin-1. The latter is thought to be an important mediator of inflammation, pain, and tissue destruction in musculoskeletal conditions. ACS has been widely and successfully used in the local treatment of human and equine osteoarthritis and radicular compression; it has also shown promise in treating tendinopathies, muscle injuries, and tunnel widening after reconstruction of the anterior cruciate ligament. Experience suggests that autologous conditioned serum is safe and effective.

Keywords: Anterior cruciate ligament; Interleukin-1 receptor antagonist; Intra-articular therapy; Muscle injury; Osteoarthritis; Pain; Radicular compression; Tendinopathy.

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