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Editorial
. 2016 Dec 6;134(23):1863-1865.
doi: 10.1161/CIRCULATIONAHA.116.025601. Epub 2016 Oct 27.

Lnc-ing NOTCH1 to Idiopathic Calcific Aortic Valve Disease

W David Merryman  1 , Cynthia R Clark  2
Affiliations
Editorial

Lnc-ing NOTCH1 to Idiopathic Calcific Aortic Valve Disease

W David Merryman et al. Circulation. .
No abstract available

Keywords: Editorials; H19 long non-coding RNA; Notch1 receptor; cadherin-11; calcification of aortic valve.

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Figures

Figure
Figure
New evidence by Hadjj et al. demonstrates that idiopathic calcific aortic valve disease (CAVD) is associated with hypomethylation of the long non-coding (lnc) RNA H19, which prevents p53 from binding to the promoter region of NOTCH1, suppressing transcription. This complements previous data showing that repression of NOTCH1 leads to CAVD, likely through myofibroblast and osteogenic differentiation. CDH11 is particularly of interest as a potential therapeutic as it is an accessible cell surface protein that is enriched in both murine Notch1+/− VICs and human CAVD.
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References

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