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. 2017 Jan 4;45(D1):D415-D418.
doi: 10.1093/nar/gkw990. Epub 2016 Oct 26.

Updates in Rhea - an expert curated resource of biochemical reactions

Anne Morgat  1   2 , Thierry Lombardot  3 , Kristian B Axelsen  3 , Lucila Aimo  3 , Anne Niknejad  4 , Nevila Hyka-Nouspikel  3 , Elisabeth Coudert  3 , Monica Pozzato  3 , Marco Pagni  4 , Sébastien Moretti  4   5 , Steven Rosanoff  6 , Joseph Onwubiko  6 , Lydie Bougueleret  3 , Ioannis Xenarios  3   4   7 , Nicole Redaschi  3 , Alan Bridge  3
Affiliations

Updates in Rhea - an expert curated resource of biochemical reactions

Anne Morgat et al. Nucleic Acids Res. .

Erratum in

  • Updates in Rhea - an expert curated resource of biochemical reactions.
    Morgat A, Lombardot T, Axelsen KB, Aimo L, Niknejad A, Hyka-Nouspikel N, Coudert E, Pozzato M, Pagni M, Moretti S, Rosanoff S, Onwubiko J, Bougueleret L, Xenarios I, Redaschi N, Bridge A. Morgat A, et al. Nucleic Acids Res. 2017 Apr 20;45(7):4279. doi: 10.1093/nar/gkw1299. Nucleic Acids Res. 2017. PMID: 27980062 Free PMC article. No abstract available.

Abstract

Rhea (http://www.rhea-db.org) is a comprehensive and non-redundant resource of expert-curated biochemical reactions designed for the functional annotation of enzymes and the description of metabolic networks. Rhea describes enzyme-catalyzed reactions covering the IUBMB Enzyme Nomenclature list as well as additional reactions, including spontaneously occurring reactions, using entities from the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules. Here we describe developments in Rhea since our last report in the database issue of Nucleic Acids Research. These include the first implementation of a simple hierarchical classification of reactions, improved coverage of the IUBMB Enzyme Nomenclature list and additional reactions through continuing expert curation, and the development of a new website to serve this improved dataset.

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Figures

Figure 1.
Figure 1.
The Rhea reaction classification. The IUBMB enzyme classification (left) describes the enzyme activity sphinganine-1-phosphate aldolase (EC 4.1.2.27), which catalyzes the reaction Rhea:18596 (blue). This reaction, and other reactions including Rhea:33510, Rhea:34720 and Rhea:34746 (pink), are specific forms of the more generic reaction Rhea:40002 (grey), which lies between EC 4.1.2 and EC 4.1.2.27. Enzymes are omitted for the sake of clarity.
See this image and copyright information in PMC

References

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