Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Oct 13:6:215.
doi: 10.3389/fonc.2016.00215. eCollection 2016.

The MRI-Linear Accelerator Consortium: Evidence-Based Clinical Introduction of an Innovation in Radiation Oncology Connecting Researchers, Methodology, Data Collection, Quality Assurance, and Technical Development

Linda G W Kerkmeijer  1 , Clifton D Fuller  2 , Helena M Verkooijen  3 , Marcel Verheij  4 , Ananya Choudhury  5 , Kevin J Harrington  6 , Chris Schultz  7 , Arjun Sahgal  8 , Steven J Frank  2 , Joel Goldwein  9 , Kevin J Brown  9 , Bruce D Minsky  2 , Marco van Vulpen  1 ; MR-Linac Consortium Clinical Steering Committee
Affiliations

The MRI-Linear Accelerator Consortium: Evidence-Based Clinical Introduction of an Innovation in Radiation Oncology Connecting Researchers, Methodology, Data Collection, Quality Assurance, and Technical Development

Linda G W Kerkmeijer et al. Front Oncol. .

Abstract

An international research consortium has been formed to facilitate evidence-based introduction of MR-guided radiotherapy (MR-linac) and to address how the MR-linac could be used to achieve an optimized radiation treatment approach to improve patients' survival, local, and regional tumor control and quality of life. The present paper describes the organizational structure of the clinical part of the MR-linac consortium. Furthermore, it elucidates why collaboration on this large project is necessary, and how a central data registry program will be implemented.

Keywords: MR-linac; MRI; consortium; innovation; linear accelerator; radiotherapy.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Organizational structure of the clinical working groups in the MR-linac Consortium. CSC, Clinical Steering Committee; HCPC, Health Care Policy Committee; MAB, Methodology Advisory Board; DMTF, Data Management Task Force; TSG, Tumor Site Group.
Figure 2
Figure 2
Timeline of clinical studies within the MR-linac Consortium. Installation of MR-linacs at all consortium institutes are either ongoing or planned for 2016. Regulatory approval for the integrated MR-linac system is planned for 2017.
See this image and copyright information in PMC

References

    1. Chang JY, Senan S, Paul MA, Mehran RJ, Louie AV, Balter P, et al. Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials. Lancet Oncol (2015) 16:630–7.10.1016/S1470-2045(15)70168-3 - DOI - PMC - PubMed
    1. Lagendijk JJ, Raaymakers BW, Raaijmakers AJ, Overweg J, Brown KJ, Kerkhof EM, et al. MRI/linac integration. Radiother Oncol (2008) 86:25–9.10.1016/j.radonc.2007.10.034 - DOI - PubMed
    1. Raaymakers BW, Lagendijk JJ, Overweg J, Kok JG, Raaijmakers AJ, Kerkhof EM, et al. Integrating a 1.5 T MRI scanner with a 6 MV accelerator: proof of concept. Phys Med Biol (2009) 54:N229–37.10.1088/0031-9155/54/12/N01 - DOI - PubMed
    1. Taylor H. Accelerated Access Review: Interim Report [cited 2015 Dec 11]. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/fil...
    1. Skripcak T, Belka C, Bosch W, Brink C, Brunner T, Budach V, et al. Creating a data exchange strategy for radiotherapy research: towards federated databases and anonymised public datasets. Radiother Oncol (2014) 113:303–9.10.1016/j.radonc.2014.10.001 - DOI - PMC - PubMed

LinkOut - more resources