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. 2016 Oct 18;113(42):11642-11643.
doi: 10.1073/pnas.1614173113.

Inner Workings: Combating antibiotic resistance from the ground up

Elie Dolgin

Inner Workings: Combating antibiotic resistance from the ground up

Elie Dolgin. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

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Gerry Wright and colleagues are purifying a potential antibiotic adjuvant called aspergillomarasmine A from Aspergillus fungus (pictured). Image courtesy of Andrew King.
See this image and copyright information in PMC

References

    1. King AM, et al. Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance. Nature. 2014;510(7506):503–506. - PMC - PubMed
    1. Review on Antimicrobial Resistance (2014) Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations. (HM Government, UK). Available at https://amr-review.org/sites/default/files/AMR%20Review%20Paper%20-%20Ta....
    1. Falconer SB, et al. Zinc chelation by a small-molecule adjuvant potentiates meropenem Activity in vivo against NDM-1-producing Klebsiella pneumonia. ACS Infect Dis. 2015;1(11):533–543. - PubMed
    1. Koteva K, King AM, Capretta A, Wright GD. Total synthesis and activity of the metallo-β-lactamase inhibitor aspergillomarasmine A. Angew Chem Int Ed Engl. 2016;55(6):2210–2212. - PubMed

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