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Review
. 2017 Feb;152(2):313-321.e2.
doi: 10.1053/j.gastro.2016.10.020. Epub 2016 Oct 25.

Understanding and Preventing the Global Increase of Inflammatory Bowel Disease

Gilaad G Kaplan  1 , Siew C Ng  2
Affiliations
Review

Understanding and Preventing the Global Increase of Inflammatory Bowel Disease

Gilaad G Kaplan et al. Gastroenterology. 2017 Feb.

Erratum in

  • Correction.
    [No authors listed] [No authors listed] Gastroenterology. 2017 Jun;152(8):2084. doi: 10.1053/j.gastro.2017.05.018. Epub 2017 May 24. Gastroenterology. 2017. PMID: 28549820 No abstract available.

Abstract

The inflammatory bowel diseases (IBDs) are contemporary conditions of industrialized societies. The prevalence of IBD continues to increase steadily in Western countries, and newly industrialized countries have a rapidly increasing incidence. The global spread of IBD appears to associate with Westernization of diets and environments, which affects the intestinal microbiome and increases the risk of IBD in genetically susceptible individuals. It is important to increase our understanding of these events to slow progression of IBD. We present a long-term plan to develop interventions that slow or stop the global increase in the incidence of IBD.

Keywords: Crohn’s Disease; Gene–Environment Interaction; Microbiota; Ulcerative Colitis.

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