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Review
. 2016 Nov;36(11):5623-5637.
doi: 10.21873/anticanres.11146.

Discovery of Anticancer Agents of Diverse Natural Origin

A Douglas Kinghorn  1   2 , Esperanza J Carcache DE Blanco  3 , David M Lucas  2   4 , H Liva Rakotondraibe  3 , Jimmy Orjala  5 , D Doel Soejarto  5   6 , Nicholas H Oberlies  7 , Cedric J Pearce  8 , Mansukh C Wani  9 , Brent R Stockwell  10   11 , Joanna E Burdette  5 , Steven M Swanson  12 , James R Fuchs  3 , Mitchell A Phelps  3   2 , Lihui Xu  2 , Xiaoli Zhang  2   4 , Young Yongchun Shen  13
Affiliations
Review

Discovery of Anticancer Agents of Diverse Natural Origin

A Douglas Kinghorn et al. Anticancer Res. 2016 Nov.

Abstract

Recent progress is described in an ongoing collaborative multidisciplinary research project directed towards the purification, structural characterization, chemical modification, and biological evaluation of new potential natural product anticancer agents obtained from a diverse group of organisms, comprising tropical plants, aquatic and terrestrial cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which initial extracts, chromatographic fractions, and purified isolated compounds of these acquisitions are tested. Several promising biologically active lead compounds from each major organism class investigated are described, and these may be seen to be representative of a very wide chemical diversity.

Keywords: Natural products; cyanobacteria; fungi; potential anticancer activity; review; tropical plants.

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Figures

Figure 1
Figure 1
New organizational scheme of the program project.
Figure 2
Figure 2
Structures of compounds isolated from tropical plants. 1: Phyllanthusmin D, 2: phyllanthusmin E, 3: phyllanthusmin C, 4: sphenostylisin A, 5: perviridisin B, 6: silvestrol.
Figure 3
Figure 3
Structures of compounds isolated from freshwater (7–10) and cultured (11, 12) cyanobacteria. 7: Carbamidocyclophane F, 8: carbamidocyclophane G, 9: trichormamide A, 10: trichormamide B 11: ambiguine I isonitrile; 12: hapalindole H.
Figure 4
Figure 4
Structures of compounds isolated from cultured filamentous fungi. 13: Atroviridin D, 14: obionin B, 15: thielavin B methyl ester, 16: 7-epi-zeaenol, 17: trichodepsipeptide B, 18: acremoxanthone D, 19: verticillin H, 20, verticillin A.
See this image and copyright information in PMC

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