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Review
. 2017;9(1):3-11.
doi: 10.1159/000451026. Epub 2016 Oct 29.

Non-Pulmonary Immune Functions of Surfactant Proteins A and D

Sylvia Ujma  1 , William G C Horsnell, Arieh A Katz, Howard W Clark, Georgia Schäfer
Affiliations
Review

Non-Pulmonary Immune Functions of Surfactant Proteins A and D

Sylvia Ujma et al. J Innate Immun. 2017.

Abstract

Surfactant proteins A (SP-A) and D (SP-D) are established as essential components of our innate immune system for protecting the lung from pathogens and allergens. They essentially exert their protective functions by regulating pulmonary homeostasis. Both proteins are however widely expressed throughout the body, including the female reproductive tract, urinary tract, gastrointestinal tract, the eye, ear, nasal compartment, central nervous system, the coronary artery and the skin. The functions of SP-A and SP-D at these sites are a relatively underinvestigated area, but it is emerging that both SP-A and SP-D contribute significantly to the regulation of inflammation and protection from infection at these sites. This review presents our current understanding of the roles of SP-A and SP-D in non-pulmonary sites.

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References

    1. Pattle RE. Properties, function and origin of the alveolar lining layer. Nature. 1955;175:1125–1126. - PubMed
    1. Wright JR. Immunoregulatory functions of surfactant proteins. Nat Rev Immunol. 2005;5:58–68. - PubMed
    1. Kishore U, Greenhough TJ, Waters P, Shrive AK, Ghai R, Kamran MF, Bernal AL, Reid KB, Madan T, Chakraborty T. Surfactant proteins SP-A and SP-D: structure, function and receptors. Mol Immunol. 2006;43:1293–1315. - PubMed
    1. Jäkel A, Qaseem AS, Kishore U, Sim RB. Ligands and receptors of lung surfactant proteins SP-A and SP-D. Front Biosci (Landmark Ed) 2013;18:1129–1140. - PubMed
    1. Head JF, Mealy TR, McCormack FX, Seaton BA. Crystal structure of trimeric carbohydrate recognition and neck domains of surfactant protein A. J Biol Chem. 2003;278:43254–43260. - PubMed

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