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Review
. 2017 Feb;55(2):360-368.
doi: 10.1128/JCM.01057-16. Epub 2016 Oct 19.

Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases

Zachary E Holcomb  1 , Ephraim L Tsalik  2   3   4 , Christopher W Woods  2   3   5 , Micah T McClain  6   3   5
Affiliations
Review

Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases

Zachary E Holcomb et al. J Clin Microbiol. 2017 Feb.

Abstract

Emerging pandemic infectious threats, inappropriate antibacterial use contributing to multidrug resistance, and increased morbidity and mortality from diagnostic delays all contribute to a need for improved diagnostics in the field of infectious diseases. Historically, diagnosis of infectious diseases has relied on pathogen detection; however, a novel concept to improve diagnostics in infectious diseases relies instead on the detection of changes in patterns of gene expression in circulating white blood cells in response to infection. Alterations in peripheral blood gene expression in the infected state are robust and reproducible, yielding diagnostic and prognostic information to help facilitate patient treatment decisions.

Keywords: diagnostics; gene expression.

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Figures

FIG 1
FIG 1
Development of a biomarker signature.
FIG 2
FIG 2
Characteristics of a diagnostic test. TLDA, TaqMan low-density array.
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See this image and copyright information in PMC

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