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. 2016 Dec 27;61(1):e03005-15.
doi: 10.1128/AAC.03005-15. Print 2017 Jan.

Evaluation of the Carba NP Test in Oregon, 2013

Karim E Morey  1 , Robert Vega  2 , P Maureen Cassidy  3 , Genevieve L Buser  3 , Jaipreet K Rayar  4 , Jeffrey A Myers  4 , Scott J Weissman  4 , Zintars G Beldavs  3 , Christopher D Pfeiffer  5   6
Affiliations

Evaluation of the Carba NP Test in Oregon, 2013

Karim E Morey et al. Antimicrob Agents Chemother. .

Abstract

Carbapenem-resistant Enterobacteriaceae (CRE) are an urgent public health threat. We evaluated the capacity of the Carba NP test to detect carbapenemase production in 206 isolates: 143 Enterobacteriaceae identified by Oregon's CRE surveillance program in 2013 and 63 known carbapenemase-positive organisms. Overall, test sensitivity and specificity were 89% (59/66 isolates; 95% confidence interval [CI], 81 to 97%) and 100% (140/140 isolates; 95% CI, 98 to 100%), respectively. All KPC, NDM-1, VIM, and IMP producers but no (0/7 isolates) OXA-48-like strains were Carba NP positive prior to a post hoc protocol modification. We subsequently incorporated Carba NP into Oregon's CRE screening algorithm.

Keywords: Carba NP; IMP; KPC; NDM; OXA-48; VIM; carbapenemase.

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