Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Oct 10;5(1):1757.
doi: 10.1186/s40064-016-2869-y. eCollection 2016.

Evaluation of cord blood irisin levels in term newborns with small gestational age and appropriate gestational age

Esengul Keleş  1 , Filiz Fatime Turan  2
Affiliations

Evaluation of cord blood irisin levels in term newborns with small gestational age and appropriate gestational age

Esengul Keleş et al. Springerplus. .

Abstract

Background: Most recently, a novel myokine, named irisin, was identified in human that expressed by skeletal muscle after exercise. Irisin increases energy expenditure by turning white adipose tissue into brown adipose tissue. Thus improves carbohydrate homeostasis in humans. Irisin is considered as a potential biomarker for obesity and metabolic syndrome. In recent years, numerous studies have been conducted about irisin with adults, although number of studies with newborns is limited.

Objective: To evaluate cord blood irisin level with small gestational age (SGA) and appropriate gestational age (AGA) in term newborns.

Methods: A cross-sectional study of 34 AGA and 34 SGA term newborns who were born in (1-30) December 2015 in Fatih University Hospital. Estimated fetal weight were calculated using the Hadlock formula by gynecologists to pregnant women in second trimester. All the babies were classified at birth as SGA or AGA. SGA was defined according to the Lubchenco scale for gender and gestational age. We collected umbilical cord blood at the time of delivery. Cord blood irisin levels were measured using commercial enzyme-linked immunosorbent assays in our hospital laboratory.

Results: Cord blood irisin levels were significantly lower in SGA group [median 30 (25 ± 8) ng/ml] than in AGA group [median 40 (39 ± 13) ng/ml, p < 0.001]. No statistically significant differences were observed among the groups in terms of the demographic features (gender, mode of delivery, gestational weeks, 1-5 min Apgar score) (p > 0.05). Mothers with gestational diabetes, hypertension, asthma, chronic disease, use of drug or a history of smoking exposure were excluded from the study. When the study data were evaluated, Yates Continuity Correction and Fisher's exact tests were used in descriptive statistical methods and for comparison of qualitative data.

Conclusion: Our results support the idea that irisin have a physiologic role in neonates. Low level of irisin is associated with the impaired carbohydrate metabolism in term infants with SGA. However, further studies with larger series are warranted to confirm this.

Keywords: AGA; Cord blood irisin level; SGA; Term infant.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Cord irisin level in AGA and SGA group
See this image and copyright information in PMC

References

    1. Barker DJ. The origins of the developmental origins theory. J Intern Med. 2007;261:412–417. doi: 10.1111/j.1365-2796.2007.01809.x. - DOI - PubMed
    1. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481:463–468. doi: 10.1038/nature10777. - DOI - PMC - PubMed
    1. Druet C, Stettler N, Sharp S. Prediction of childhood obesity by infancy weight gain: an individual-level meta-analysis. Paediatr Perinat Epidemiol. 2012;26:19–26. doi: 10.1111/j.1365-3016.2011.01213.x. - DOI - PubMed
    1. Ebert T, Stepan H, Schrey S, Kralisch S, Hindricks J, Hopf L, et al. Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery. Cytokine. 2014;65:153–158. doi: 10.1016/j.cyto.2013.11.009. - DOI - PubMed
    1. Garces MF, Peralta JJ, Ruiz-Linares CE, Lozano AR, Poveda NE, Torres-Sierra AL, et al. Irisin levels during pregnancy and changes associated with the development of preeclampsia. J Clin Endocrinol Metab. 2014;99:2113–2119. doi: 10.1210/jc.2013-4127. - DOI - PubMed

LinkOut - more resources