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Review
. 2016 Nov;18(11):69.
doi: 10.1007/s11926-016-0618-4.

The Complex Role of the Lung in the Pathogenesis and Clinical Outcomes of Rheumatoid Arthritis

Lindsay B Kelmenson  1 , M Kristen Demoruelle  2 , Kevin D Deane  2   3
Affiliations
Review

The Complex Role of the Lung in the Pathogenesis and Clinical Outcomes of Rheumatoid Arthritis

Lindsay B Kelmenson et al. Curr Rheumatol Rep. 2016 Nov.

Abstract

While the primary manifestation of rheumatoid arthritis (RA) is articular disease, extra-articular disease may also occur. In particular, pulmonary disease is a frequent extra-articular manifestation of seropositive RA and a leading cause of morbidity and mortality in this population. This review will highlight studies published in the last several years and will, in particular, discuss the relationship of antibodies to citrullinated protein/peptide antigens (ACPA) and lung disease in patients with RA. We will also review the data regarding the potential role of the lung and generation of RA-related autoantibodies in a period of disease development termed "preclinical RA." Finally, we will discuss the role of ACPA and other Abs in non-RA pulmonary diseases and discuss a research agenda for next steps in the understanding and management of the lung in RA.

Keywords: Anti-citrullinated protein antibodies; Lung; Rheumatoid arthritis; Rheumatoid factor.

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References

    1. Ann Rheum Dis. 2015 Sep;74(9):1772-7 - PubMed
    1. Clin Rheumatol. 2015 Sep;34(9):1529-36 - PubMed
    1. Ann Rheum Dis. 2011 Mar;70(3):508-11 - PubMed
    1. Curr Microbiol. 2013 Aug;67(2):170-6 - PubMed
    1. J Allergy Clin Immunol. 2016 Jan;137(1):28-34 - PubMed

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