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. 2017 Mar;14(3).
doi: 10.1002/cbdv.201600276. Epub 2017 Feb 16.

Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation

Iura M Alves  1 , Lucas S Abreu  2 , Cinara O S Costa  3 , Mireille Le Hyaric  4 , Maria Lenise S Guedes  5 , Milena B P Soares  3 , Daniel P Bezerra  3 , Eudes S Velozo  1   2
Affiliations

Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation

Iura M Alves et al. Chem Biodivers. 2017 Mar.

Abstract

One new chromone 3,3-dimethylallylspatheliachromene methyl ether (1), as well as five known chromones, 6-(3-methylbut-2-enyl) allopteroxylin methyl ether (2), 6-(3-methylbut-2-enyl) allopteroxylin (3), 3,3-dimethylallylspatheliachromene (4), 5-O-methylcneorumchromone K (5) and spatheliabischromene (6), two alkaloids, 8-methoxy-N-methylflindersine (7) and 8-methoxyflindersine (8), and two limonoids, limonin diosphenol (9) and rutaevin (10), were isolated from Dictyoloma vandellianum A. Juss (Rutaceae). Cytotoxic activities towards tumor cell lines B16-F10, HepG2, K562 and HL60 and non-tumor cells PBMC were evaluated for compounds 1 - 6. Compound 1 was the most active showing IC50 values ranging from 6.26 to 14.82 μg/ml in B16-F10 and K562 cell lines, respectively, and presented IC50 value of 11.65 μg/ml in PBMC cell line.

Keywords: Dictyoloma; Alkaloids; Chromones; Cytotoxic activities; Limonoids; Rutaceae.

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