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Review
. 2017 Jan 2;8(1):34-45.
doi: 10.1080/19491034.2016.1252893. Epub 2016 Oct 31.

Shared mechanisms in physiological and pathological nucleoplasmic reticulum formation

Marek Mateusz Drozdz  1 , David John Vaux  1
Affiliations
Review

Shared mechanisms in physiological and pathological nucleoplasmic reticulum formation

Marek Mateusz Drozdz et al. Nucleus. .

Abstract

The mammalian nuclear envelope (NE) can develop complex dynamic membrane-bounded invaginations in response to both physiological and pathological stimuli. Since the formation of these nucleoplasmic reticulum (NR) structures can occur during interphase, without mitotic NE breakdown and reassembly, some other mechanism must drive their development. Here we consider models for deformation of the interphase NE, together with the evidence for their potential roles in NR formation.

Keywords: NE; NR; chromosome territories; cytoskeleton; gene expression; membrane curvature; nuclear envelope; nucleoplasmic reticulum.

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Figures

Figure 1.
Figure 1.
Super resolution light microscopy on normal human dermal fibroblasts, labeled with anti-lamin B1 antibody (green), anti-lamin A/C antibody (orange) and DAPI (blue). White arrowheads point to intranuclear NR tubules. Scale bar, 2 µm.
Figure 2.
Figure 2.
Schematic representation of nucleus with possible mechanisms driving NR formation. (A) Pushing the NE by cytoskeleton (red) as visualised by yellow arrow; (B) Pulling the NE by chromatin movement (green), movement indicated by yellow arrow; (C) Focal and de novo assembly and growth (yellow arrow) of NR invaginations (red) by dedicated machinery.
See this image and copyright information in PMC

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