PGAM5: a new player in immune-mediated liver injury
- PMID: 27797941
- PMCID: PMC5479066
- DOI: 10.1136/gutjnl-2016-312775
PGAM5: a new player in immune-mediated liver injury
Keywords: AUTOIMMUNE HEPATITIS; CELL DEATH.
Conflict of interest statement
Comment on
-
PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury.Gut. 2017 Apr;66(4):716-723. doi: 10.1136/gutjnl-2015-311247. Epub 2016 Aug 26. Gut. 2017. PMID: 27566130
Similar articles
-
PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury.Gut. 2017 Apr;66(4):716-723. doi: 10.1136/gutjnl-2015-311247. Epub 2016 Aug 26. Gut. 2017. PMID: 27566130
-
Butylphthalide ameliorates experimental autoimmune encephalomyelitis by suppressing PGAM5-induced necroptosis and inflammation in microglia.Biochem Biophys Res Commun. 2018 Feb 26;497(1):80-86. doi: 10.1016/j.bbrc.2018.02.024. Epub 2018 Feb 3. Biochem Biophys Res Commun. 2018. PMID: 29407174
-
Apoptosis Inducing Factor Binding Protein PGAM5 Triggers Mitophagic Cell Death That Is Inhibited by the Ubiquitin Ligase Activity of X-Linked Inhibitor of Apoptosis.Biochemistry. 2016 Jun 14;55(23):3285-302. doi: 10.1021/acs.biochem.6b00306. Epub 2016 Jun 2. Biochemistry. 2016. PMID: 27218139
-
Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis.J Immunol Res. 2015;2015:479703. doi: 10.1155/2015/479703. Epub 2015 May 28. J Immunol Res. 2015. PMID: 26106627 Free PMC article. Review.
-
Pathology of immune-mediated liver injury.Dig Dis. 2010;28(1):57-62. doi: 10.1159/000282065. Epub 2010 May 7. Dig Dis. 2010. PMID: 20460891 Review.
Cited by
-
Ponicidin Promotes Hepatocellular Carcinoma Mitochondrial Apoptosis by Stabilizing Keap1-PGAM5 Complex.Adv Sci (Weinh). 2024 Oct;11(38):e2406080. doi: 10.1002/advs.202406080. Epub 2024 Aug 8. Adv Sci (Weinh). 2024. PMID: 39116422 Free PMC article.
-
Drp1-mediated mitochondrial fission promotes carbon tetrachloride-induced hepatic fibrogenesis in mice.Toxicol Res (Camb). 2022 May 23;11(3):486-497. doi: 10.1093/toxres/tfac027. eCollection 2022 Jun. Toxicol Res (Camb). 2022. PMID: 35782650 Free PMC article.
-
PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism and liver cancer proliferation.Acta Biochim Biophys Sin (Shanghai). 2023 Aug 15;55(9):1370-1379. doi: 10.3724/abbs.2023155. Acta Biochim Biophys Sin (Shanghai). 2023. PMID: 37580952 Free PMC article.
-
Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin-2 dephosphorylation and impairing mitochondrial quality control.Clin Transl Med. 2024 Aug;14(8):e1806. doi: 10.1002/ctm2.1806. Clin Transl Med. 2024. PMID: 39143739 Free PMC article.
-
The deubiquitinating enzyme USP11 regulates breast cancer progression by stabilizing PGAM5.Breast Cancer Res. 2024 Sep 19;26(1):135. doi: 10.1186/s13058-024-01892-9. Breast Cancer Res. 2024. PMID: 39300548 Free PMC article.
References
-
- GW He, Günther C, Kremer AE, et al. PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury. Gut. 2016 Aug 26; pii: gutjnl-2015-311247. [Epub ahead of print] - PubMed
-
- Galluzzi L, Kepp O, Kroemer G. RIP kinases initiate programmed necrosis. J Mol Cell Biol. 2009;1:8–10. - PubMed
-
- Wang Z, Jiang H, Chen S, et al. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell. 2012;148:228–43. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources