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Comment
. 2017 Apr;66(4):567-568.
doi: 10.1136/gutjnl-2016-312775. Epub 2016 Oct 19.

PGAM5: a new player in immune-mediated liver injury

Anup Ramachandran  1 , Hartmut Jaeschke  1
Affiliations
Comment

PGAM5: a new player in immune-mediated liver injury

Anup Ramachandran et al. Gut. 2017 Apr.
No abstract available

Keywords: AUTOIMMUNE HEPATITIS; CELL DEATH.

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Conflict of interest statement

Competing interests: None declared.

Comment on

References

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    1. Galluzzi L, Kepp O, Kroemer G. RIP kinases initiate programmed necrosis. J Mol Cell Biol. 2009;1:8–10. - PubMed
    1. Wang Z, Jiang H, Chen S, et al. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell. 2012;148:228–43. - PubMed
    1. Takeda K, Komuro Y, Hayakawa T, et al. Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. Proc Natl Acad Sci U S A. 2009;106:12301–5. - PMC - PubMed
    1. Lu W, Sun J, Yoon JS, et al. Mitochondrial protein PGAM5 regulates mitophagic protection against cell necroptosis. PLoS One. 2016;11:e0147792. - PMC - PubMed

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