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. 2016 Oct 26;8(362):362ps17.
doi: 10.1126/scitranslmed.aaf9246.

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

Yves Pommier  1 , Mark J O'Connor  2 , Johann de Bono  3
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Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

Yves Pommier et al. Sci Transl Med. .

Erratum in

Abstract

Poly(ADP-ribose) polymerase (PARP) inhibitors are the first DNA damage response targeted agents approved for cancer therapy. Here, we focus on their molecular mechanism of action by PARP "trapping" and what this means for both clinical monotherapy and combination with chemotherapeutic agents.

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