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Comment
. 2016 Oct 19;36(42):10726-10728.
doi: 10.1523/JNEUROSCI.2425-16.2016.

Balancing Dendrite Morphogenesis and Neuronal Migration during Cortical Development

Shan Meltzer  1 , Chao Chen  2
Affiliations
Comment

Balancing Dendrite Morphogenesis and Neuronal Migration during Cortical Development

Shan Meltzer et al. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
A summary of the findings of Hoshiba et al. (2016). High expression of Sox11 in newly born neurons inhibits dendritic morphogenesis and promotes migration into the cortical plate in the cerebral cortex. The authors propose that the end of migration triggers the reduction of Sox11, thereby allowing dendrite morphogenesis. Precocious suppression of Sox11 expression leads to migration defects as well as increases in dendritic growth. This suggests that Sox11 controls the balance between dendrite morphogenesis and migration during development. VZ, Ventricular zone; SVZ, subventricular zone; IZ, intermediate zone.
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References

    1. Arikkath J. Molecular mechanisms of dendrite morphogenesis. Front Cell Neurosci. 2012;6:61. doi: 10.3389/fncel.2012.00061. - DOI - PMC - PubMed
    1. Campbell DS, Stringham SA, Timm A, Xiao T, Law MY, Baier H, Nonet ML, Chien CB. Slit1a inhibits retinal ganglion cell arborization and synaptogenesis via Robo2-dependent and -independent pathways. Neuron. 2007;55:231–245. doi: 10.1016/j.neuron.2007.06.034. - DOI - PubMed
    1. Chen C, Lee GA, Pourmorady A, Sock E, Donoghue MJ. Orchestration of neuronal differentiation and progenitor pool expansion in the developing cortex by SoxC genes. J Neurosci. 2015;35:10629–10642. doi: 10.1523/JNEUROSCI.1663-15.2015. - DOI - PMC - PubMed
    1. Chen C, Jin J, Lee GA, Silva E, Donoghue M. Cross-species functional analyses reveal shared and separate roles for Sox11 in frog primary neurogenesis and mouse cortical neuronal differentiation. Biol Open. 2016;5:409–417. doi: 10.1242/bio.015404. - DOI - PMC - PubMed
    1. Coles CH, Shen Y, Tenney AP, Siebold C, Sutton GC, Lu W, Gallagher JT, Jones EY, Flanagan JG, Aricescu AR. Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension. Science. 2011;332:484–488. doi: 10.1126/science.1200840. - DOI - PMC - PubMed

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