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Review
. 2016 Nov 15;129(22):4159-4163.
doi: 10.1242/jcs.192054. Epub 2016 Oct 31.

The integrin adhesome network at a glance

Edward R Horton  1 , Jonathan D Humphries  1 , Jenny James  1 , Matthew C Jones  1 , Janet A Askari  1 , Martin J Humphries  2
Affiliations
Review

The integrin adhesome network at a glance

Edward R Horton et al. J Cell Sci. .

Abstract

The adhesion nexus is the site at which integrin receptors bridge intracellular cytoskeletal and extracellular matrix networks. The connection between integrins and the cytoskeleton is mediated by a dynamic integrin adhesion complex (IAC), the components of which transduce chemical and mechanical signals to control a multitude of cellular functions. In this Cell Science at a Glance article and the accompanying poster, we integrate the consensus adhesome, a set of 60 proteins that have been most commonly identified in isolated IAC proteomes, with the literature-curated adhesome, a theoretical network that has been assembled through scholarly analysis of proteins that localise to IACs. The resulting IAC network, which comprises four broad signalling and actin-bridging axes, provides a platform for future studies of the regulation and function of the adhesion nexus in health and disease.

Keywords: Adhesion; Adhesome; Cytoskeleton; Integrin; Integrin adhesion complex.

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Conflict of interest statement

The authors declare no competing or financial interests.

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