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Review
. 2016 Oct 17:9:253-256.
doi: 10.2147/IJNRD.S113219. eCollection 2016.

Biomarkers in critical illness: have we made progress?

Patrick M Honore  1 , Rita Jacobs  1 , Inne Hendrickx  1 , Elisabeth De Waele  1 , Viola Van Gorp  1 , Olivier Joannes-Boyau  2 , Jouke De Regt  1 , Willem Boer  3 , Herbert D Spapen  1
Affiliations
Review

Biomarkers in critical illness: have we made progress?

Patrick M Honore et al. Int J Nephrol Renovasc Dis. .

Abstract

Biomarkers have emerged as exemplary key players in translational medicine. Many have been assessed for timely recognition, early treatment, and adequate follow-up for a variety of pathologies. Biomarker sensitivity has improved considerably over the last years but specificity remains poor, in particular when two "marker-sensitive" conditions overlap in one patient. Biomarker research holds an enormous potential for diagnostic and prognostic purposes in postoperative and critically ill patients who present varying degrees of inflammation, infection, and concomitant (sub)acute organ dysfunction or failure. Despite a remarkable progress in development and testing, biomarkers are not yet ready for routine use at the bedside.

Keywords: ARDS; acute kidney injury; biomarkers; sepsis.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

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