Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Oct;14(4):358-364.
doi: 10.5217/ir.2016.14.4.358. Epub 2016 Oct 17.

The submucosal fibrosis: what does it mean for colorectal endoscopic submucosal dissection?

Affiliations

The submucosal fibrosis: what does it mean for colorectal endoscopic submucosal dissection?

Eun Kyoung Kim et al. Intest Res. 2016 Oct.

Abstract

Background/aims: Endoscopic submucosal dissection (ESD) allows removal of colorectal epithelial neoplasms en bloc regardless of size. Colorectal ESD is a difficult procedure because of technical difficulties and risks of complications. This study aimed to assess the relationship between ESD outcome and degree of submucosal fibrosis.

Methods: Patients with colorectal tumors undergoing ESD and their medical records were reviewed retrospectively. The degree of submucosal fibrosis was classified into three types. The relationship between ESD outcome and degree of submucosal fibrosis was analyzed.

Results: ESD was performed in 158 patients. Thirty-eight cases of F0 (no) fibrosis (24.1%) and 46 cases of F2 (severe) fibrosis (29.1%) were observed. Complete resection was achieved for 138 lesions (87.3%). Multivariate analysis demonstrated that submucosal invasion of tumor and histology of carcinoma were independent risk factors for F2 fibrosis. Severe fibrosis was an independent risk factor for incomplete resection.

Conclusions: Severe fibrosis is an important factor related to incomplete resection during colorectal ESD. In cases of severe fibrosis, the rate of complete resection was low even when ESD was performed by an experienced operator. Evaluation of submucosal fibrosis may be helpful to predict the submucosal invasion of tumors and technical difficulties in ESD.

Keywords: Colorectal neoplasms; Endoscopic submucosal dissection; Risk factors; Submucosal fibrosis.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1. Degrees of endoscopic submucosal fibrosis in early colorectal tumors. (A) F0, no fibrosis, which manifests as a transparent submucosal layer. (B) F1, mild fibrosis, which appears as a white web-like structure in the transparent submucosal layer. (C) F2, severe fibrosis, which appears as a white muscular-like structure without a transparent submucosal layer.

References

    1. Isomoto H, Shikuwa S, Yamaguchi N, et al. Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study. Gut. 2009;58:331–336. - PubMed
    1. Chung IK, Lee JH, Lee SH, et al. Therapeutic outcomes in 1000 cases of endoscopic submucosal dissection for early gastric neoplasms: Korean ESD Study Group multicenter study. Gastrointest Endosc. 2009;69:1228–1235. - PubMed
    1. Niimi K, Fujishiro M, Kodashima S, et al. Long-term outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms. Endoscopy. 2010;42:723–729. - PubMed
    1. Tanaka S, Oka S, Chayama K. Colorectal endoscopic submucosal dissection: present status and future perspective, including its differentiation from endoscopic mucosal resection. J Gastroenterol. 2008;43:641–651. - PubMed
    1. Fujishiro M, Yahagi N, Nakamura M, et al. Endoscopic submucosal dissection for rectal epithelial neoplasia. Endoscopy. 2006;38:493–497. - PubMed

LinkOut - more resources