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Case Reports
. 2016 Summer;11(3):291-295.

Meningioangiomatosis in an otherwise healthy 13 year-old boy: A case report with emphasis on histopathological findings

Dorna Motevalli  1 , Naser Kamalian  1 , Seyed Mohammad Tavangar  1
Affiliations
Case Reports

Meningioangiomatosis in an otherwise healthy 13 year-old boy: A case report with emphasis on histopathological findings

Dorna Motevalli et al. Iran J Pathol. 2016 Summer.

Abstract

Meningioangiomatosis is regarded as a rare benign hamartomatous condition mostly involving the cerebral cortex and overlying leptomeninges. A strong association of MA with neurofibromatosis type 2 has been documented in published articles. Herein we report a case of an otherwise healthy 13-year-old boy with no family history or stigmata of neurofibromatosis who presented with intractable seizures. MRI revealed a 2x2 cm mass lesion in the frontal lobe. The patient underwent complete surgical resection of the lesion. Although the primary radiologic impression of the lesion was glioma, pathological evaluation of the resected specimen showed mainly proliferation of meningothelial cells and fibroblast-like cells with many thickened blood vessels, which are typical for diagnosis of meningioangiomatosis. After surgical removal of the lesion, the patient is free of seizures.

Keywords: Meningioangiomatosis sporadic; Seizure histopathology.

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Figures

Fig. 1
Fig. 1
Figure shows increased cortical vascularity and proliferation of small-size vasculature in the cortex, No mitotic activity, no necrosis, no marked pleomorphism is seen (Hematoxylin and Eosin, 100X
Fig. 2
Fig. 2
Irregularly thick walled hyalinized blood vessels are noted. (Hematoxylin and Eosin, 400X
Fig. 3
Fig. 3
There is perivascular cuff which is a consequence of prominent perivascular meningothelial cell proliferation. (Hematoxylin and Eosin, 400X
Fig. 4
Fig. 4
Calcified blood vessels are seen in the periphery of the lesion (Hematoxylin and Eosin, 400X
See this image and copyright information in PMC

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