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. 2016 Apr;46(2):52-57.
doi: 10.4274/tjo.99897. Epub 2016 Apr 5.

Clinical Characteristics of Fuchs' Uveitis Syndrome

Pınar Nalçacıoğlu  1 , Pınar Çakar Özdal  2 , Mert Şimşek  2
Affiliations

Clinical Characteristics of Fuchs' Uveitis Syndrome

Pınar Nalçacıoğlu et al. Turk J Ophthalmol. 2016 Apr.

Abstract

Objectives: To evaluate the clinical and demographic properties of Fuchs' uveitis syndrome (FUS) in Turkish patients.

Materials and methods: The medical records of 161 patients with FUS followed in the Uveitis Division of Ulucanlar Eye Hospital between 1996 and 2014 were respectively reviewed. The mean age at diagnosis, sex, the number of affected eyes, follow-up period, clinical findings at presentation, complications during the follow-up period, medical and surgical treatments, and best corrected visual acuity at the initial and final visits were recorded.

Results: The study included 171 eyes of 161 patients diagnosed with FUS. Of the patients, 94 (58.4%) were female and 67 (41.6%) were male. The mean age at presentation was 35.2±11.0 (11-65) years. The mean follow-up period was 23.5±32.8 (2-216) months. Ten (6.2%) patients had bilateral involvement. The most common symptoms at presentation were decreased visual acuity or blurred vision in 63 (39.1%) and floaters in 19 (11.8%) patients. Clinical findings at presentation included diffuse small, round, white keratic precipitates in 128 (74.8%) eyes, anterior chamber reaction in 82 (47.9%), vitreous cells in 122 (71.3%), heterochromia in 47 (27.4%) and iris nodules in 32 (18.7%) eyes. During the follow-up period, elevated intraocular pressure occured in 31 (18.1%) eyes and the most common complication was cataract development (89 eyes, 52.0%).

Conclusion: Heterochromia was observed in 27.4% of patients in our study. However, the diffuse small, round keratic precipitates, low-grade anterior chamber reaction and varying degrees of vitreous reaction are more common clinical characteristics that are helpful in making the diagnosis.

Keywords: Cataract; Fuchs’ uveitis syndrome; complications; heterochromia; intraocular pressure.

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Conflict of interest statement

No conflict of interest was declared by the authors. Financial Disclosure: The authors declared that this study received no financial support.

Figures

Figure 1
Figure 1. Diffuse, medium-sized, white, round keratic precipitates in a case of Fuchs’ uveitis syndrome
Figure 2
Figure 2. Iris atrophy is more pronounced in the pupillary margin
Figure 3
Figure 3. Koeppe nodules at the pupillary border and Busacca nodules in the iris stroma in a Fuchs’ uveitis syndrome patient
Figure 4
Figure 4. A Fuchs’ uveitis syndrome patient with posterior subcapsular cataract development
See this image and copyright information in PMC

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