[Efficacy and safety of JAK inhibitor ruxolitinib in Chinese patients with myelofibrosis: results of a 1-year follow-up of A2202]

Abstract

Objective: To evaluate the efficacy and safety of ruxolitinib in Chinese myelofibrosis patients. Methods: This study enrolled 63 Chinese patients(32 males and 31 females)in total, whose median age was 55(25-79)years. The initial dose of ruxolitinib was 30mg/d(25 patients)with a baseline of PLT(100-200)×10⁹/L and 40 mg/d(38 patients)with a baseline of PLT>200×10⁹/L. Spleen volume, quality of life(QOL)and symptoms were evaluated by MRI/CT, European Organization for Research and Treatment of Cancer QOL Questionnaire Core 30(EORTC QLQ-C30)and MF Symptom Assessment Form(MFSAF)v2.0 questionnaire. Results: At the time of this analysis(follow-up of 12 months), 47 patients(74.6%)were still receiving treatment, 25 patients(39.7%)achieved ≥35% reduction in spleen volume from baseline. First time to achieve≥35% reduction was 12.71(95% CI 12.14- 35.00)weeks. During the treatment, 85.7%(54 /63)of patients achieved reduction in spleen volume in different extent, the median optimal spleen volume reduction was 35.5% and the median spleen volume reduction was 34.7% at week 48. 53.1%(26/49)of patients achieved ≥50% reduction in spleen volume from baseline in total symptom score and QOL was improved at week 48. The most common hematologic adverse events were anemia and thrombocytopenia, which merely resulted in discontinuation of treatment. Non-hematologic adverse events were almost grade 1/2. Conclusions: These data indicated that ruxolitinib treatment provided durable reductions in spleen volume and improvement in symptoms in Chinese myelofibrosis patients, and the adverse events were tolerated. Clinical trial registration: Novartis pharma(NCT01392443).

图1. 骨髓纤维化患者芦可替尼的平均剂量

图2. 接受芦可替尼治疗骨髓纤维化患者症状评估评分较基线的中位降低比例

1：盗汗；2：瘙痒；3：腹部不适；4：左上腹肋缘下疼痛；5：早饱感；6：骨骼或肌肉疼痛；7：不活跃症状