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Review
. 2017 Oct;23(7):822-827.
doi: 10.1111/odi.12606. Epub 2016 Dec 23.

Immune reconstitution inflammatory syndrome in HIV infection: taking the bad with the good

C-S Wong  1 , E S Richards  1 , L Pei  1 , I Sereti  1
Affiliations
Review

Immune reconstitution inflammatory syndrome in HIV infection: taking the bad with the good

C-S Wong et al. Oral Dis. 2017 Oct.

Abstract

In this review, we will describe the immunopathogies of immune reconstitution inflammatory syndrome, IRIS. IRIS occurs in a small subset of HIV patient, initiating combination antiretroviral therapy (ART), where immune reconstitution becomes dysregulated, resulting in an overly robust antigen-specific inflammatory reaction. We will discuss IRIS in terms of the associated coinfections: mycobacteria, cryptococci, and viruses.

Keywords: HIV; coinfection; immune reconstitution; immunology; lymphopenia; microbiology.

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Figures

Figure 1
Figure 1
Oral Kaposi sarcoma as an unmasking IRIS manifestation. Patient had no oral or skin lesions when starting ART with a CD4 count of 15 cells/μL and plasma HIV-RNA 121,410 copies/mL. After 4 weeks of ART, his CD4 count had increased to 77 cells/μL, HIV-RNA had dropped to 128 copies/mL and he had mucosal purple lesions typical of KS.
See this image and copyright information in PMC

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