Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Nov 1;5(11):e004070.
doi: 10.1161/JAHA.116.004070.

Early Denervation and Later Reinnervation of the Heart Following Cardiac Transplantation: A Review

Affiliations
Review

Early Denervation and Later Reinnervation of the Heart Following Cardiac Transplantation: A Review

Morcos Awad et al. J Am Heart Assoc. .
No abstract available

Keywords: electrophysiology; exercise; hemodynamics; imaging; nervous system autonomic; transplantation.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Reinnervation of the heart following cardiac transplantation. Cardiac reinnervation is highest in the left anterior descending (LAD) territory, followed by the left circumflex (LCX) territory, and lowest in the right coronary artery (RCA) territory.4, 11, 13, 49 It starts at the base of the anterior wall of the left ventricle (LV) and expands to the septal and lateral walls.3, 8, 9, 11, 33 The magnitude of reinnervation is highest at the anterobasal wall followed by the septal wall.7, 11 There is a gradient of reinnervation from the base to the apex of the heart.11 Ventricular reinnervation occurs prior to sinus node reinnervation.8

References

    1. Doering LV, Dracup K, Moser DK, Czer LS, Peter CT. Hemodynamic adaptation to orthostatic stress after orthotopic heart transplantation. Heart Lung. 1996;25:339–351. - PubMed
    1. Wilson RF, Christensen BV, Olivari MT, Simon A, White CW, Laxson DD. Evidence for structural sympathetic reinnervation after orthotopic cardiac transplantation in humans. Circulation. 1991;83:1210–1220. - PubMed
    1. Uberfuhr P, Ziegler S, Schwaiblmair M, Reichart B, Schwaiger M. Incomplete sympathic reinnervation of the orthotopically transplanted human heart: observation up to 13 years after heart transplantation. Eur J Cardiothorac Surg. 2000;17:161–168. - PubMed
    1. Bengel FM, Ueberfuhr P, Karja J, Schreiber K, Nekolla SG, Reichart B, Schwaiger M. Sympathetic reinnervation, exercise performance and effects of beta‐adrenergic blockade in cardiac transplant recipients. Eur Heart J. 2004;25:1726–1733. - PubMed
    1. Banner NR, Williams TD, Patel N, Chalmers J, Lightman SL, Yacoub MH. Altered cardiovascular and neurohumoral responses to head‐up tilt after heart‐lung transplantation. Circulation. 1990;82:863–871. - PubMed

MeSH terms

LinkOut - more resources