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. 2016 Oct-Dec;11(4):283-288.
doi: 10.4103/1817-1737.191874.

Ketamine versus aminophylline for acute asthma in children: A randomized, controlled trial

Abhimanyu Tiwari  1 , Vishal Guglani  1 , Kana Ram Jat  2
Affiliations

Ketamine versus aminophylline for acute asthma in children: A randomized, controlled trial

Abhimanyu Tiwari et al. Ann Thorac Med. 2016 Oct-Dec.

Abstract

Background: There is a lack of consensus regarding second-line therapy in children with acute asthma who fail to the standard therapy. Ketamine had bronchodilator property and may be useful in the treatment of acute asthma.

Objective: The objective of this study was to evaluate the efficacy and safety of ketamine as compared to aminophylline in children with acute asthma who respond poorly to the standard therapy.

Methods: This randomized controlled trial included patients with acute asthma having Pediatric Respiratory Assessment Measure (PRAM) score ≥5 at 2 h of standard therapy. The enrolled patients received either intravenous (IV) ketamine or IV aminophylline. Primary outcome measure was change in PRAM score at the end of intervention. Secondary outcome measures included adverse effects, change in PO2and PCO2, need for mechanical ventilation, and duration of hospital stay.

Results: The trial included 24 patients each in ketamine and aminophylline groups. The baseline parameters were similar between the groups. The primary outcome was similar in both the groups with a change in PRAM score of 4.00 ± 1.25 and 4.17 ± 1.68 (P = 0.699) in ketamine and aminophylline groups, respectively. The secondary outcomes were not different between the groups.

Conclusion: Ketamine and aminophylline were equally effective for children with acute asthma who responded poorly to the standard therapy.

Keywords: Acute asthma; aminophylline; children; ketamine.

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Figures

Figure 1
Figure 1
Patient flow diagram
Figure 2
Figure 2
Mean Pediatric Respiratory Assessment Measure score from enrollment to 3 h of intervention
See this image and copyright information in PMC

References

    1. GINA Report, Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma – GINA. 2015. [Last cited on 2016 Mar 27]. Available from: http://www.ginasthma.org/gina-report-global-strategyfor-asthma-managemen...
    1. BTS-SIGN Asthma Guideline-2014. [Last cited on 2016 Mar 27]. Available from: https://www.brit-thoracic.org.uk/document-library/clinical-information/a...
    1. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. [Last cited on 2016 Mar 27]. Available from: http://www.nhlbi.nih.gov/files/docs/guidelines/asthgdln.pdf .
    1. Howes MC. Ketamine for paediatric sedation/analgesia in the emergency department. Emerg Med J. 2004;21:275–80. - PMC - PubMed
    1. Roback MG, Wathen JE, Bajaj L, Bothner JP. Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: A comparison of common parenteral drugs. Acad Emerg Med. 2005;12:508–13. - PubMed