Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 Jan;79(1):114-117.
doi: 10.1097/PSY.0000000000000414.

Mitochondrial Nexus to Allostatic Load Biomarkers

Martin Picard  1 , Robert-Paul Juster, Richard P Sloan, Bruce S McEwen
Affiliations
Comment

Mitochondrial Nexus to Allostatic Load Biomarkers

Martin Picard et al. Psychosom Med. 2017 Jan.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. Relationship between mitochondrial function and glucose, lipids, and inflammation
Allostatic load biomarkers are influenced by mitochondrial activities. (1) Glucose and lipids are used as fuels and directly metabolized by mitochondria, effectively removing them from the circulation when mitochondria are functioning normally. Conversely, dysfunctional mitochondria may cause elevated circulating glucose and lipid levels, contributing to allostatic load. Dysfunctional or damaged mitochondria also produce (2) damage-associated molecular pattern molecules (DAMPs) including circulating cell-free mtDNA that directly promote inflammation by activating the immune system, or (3) activate pro-inflammatory gene expression in the cell nucleus, leading to the production of pro-inflammatory cytokines in various cell types.
See this image and copyright information in PMC

Comment on

References

    1. Wiley JF, Gruenewald TL, Karlamangla AS, Seeman TE. Modeling Multisystem Physiological Dysregulation. Psychosom Med. 2016 - PMC - PubMed
    1. Gallo LC, Fortmann AL, Mattei J. Allostatic load and the assessment of cumulative biological risk in biobehavioral medicine: challenges and opportunities. Psychosom Med. 2014;76:478–80. - PMC - PubMed
    1. Gale CR, Batty GD, Cooper SA, Deary IJ, Der G, McEwen BS, Cavanagh J. Reaction time in adolescence, cumulative allostatic load, and symptoms of anxiety and depression in adulthood: the West of Scotland Twenty-07 Study. Psychosom Med. 2015;77:493–505. - PMC - PubMed
    1. Upchurch DM, Stein J, Greendale GA, Chyu L, Tseng CH, Huang MH, Lewis TT, Kravitz HM, Seeman T. A Longitudinal Investigation of Race, Socioeconomic Status, and Psychosocial Mediators of Allostatic Load in Midlife Women: Findings From the Study of Women’s Health Across the Nation. Psychosom Med. 2015;77:402–12. - PMC - PubMed
    1. Read S, Grundy E. Allostatic load and health in the older population of England: a crossed-lagged analysis. Psychosom Med. 2014;76:490–6. - PMC - PubMed