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. 2017 Apr;31(8):861-869.
doi: 10.1080/14786419.2016.1250089. Epub 2016 Nov 3.

Secondary metabolites from Aspergillus japonicus CAM231, an endophytic fungus associated with Garcinia preussii

Jean-Bosco Jouda  1 , Judith-Laure Demgne Fopossi  2 , Francine Mediesse Kengne  2 , Céline Djama Mbazoa  1 , Christopher Golz  3 , Carsten Strohmann  3 , Simeon Kouam Fogue  4 , Jean Wandji  1
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Secondary metabolites from Aspergillus japonicus CAM231, an endophytic fungus associated with Garcinia preussii

Jean-Bosco Jouda et al. Nat Prod Res. 2017 Apr.

Abstract

Chemical investigation of Aspergillus japonicus CAM231, isolated from the leaf of Garcina preussii collected in Cameroon, yielded two new compounds; one pyrone derivative, hydroxy neovasinin (1) and one phenol derivative, asperolan (2), together with two known compounds neovasifurarone B (3) and variecolin (4). The structures of the two new compounds were established using intensive NMR spectroscopy and HRMS spectra in comparison with data found in literature. The structure of compound 1 was confirmed by single-crystal X-ray crystallographic analysis in combination with NOESY experiment. The new compounds were screened for their cytotoxic and antibacterial properties; however, the tested compounds displayed no significant activities.

Keywords: Aspergillus japonicus CAM231; endophytic fungus; secondary metabolites.

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