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. 2016 Nov 29;87(22):2317-2323.
doi: 10.1212/WNL.0000000000003371. Epub 2016 Nov 2.

Hippocampal volumes predict risk of dementia with Lewy bodies in mild cognitive impairment

Kejal Kantarci  1 , Timothy Lesnick  2 , Tanis J Ferman  2 , Scott A Przybelski  2 , Bradley F Boeve  2 , Glenn E Smith  2 , Walter K Kremers  2 , David S Knopman  2 , Clifford R Jack Jr  2 , Ronald C Petersen  2
Affiliations

Hippocampal volumes predict risk of dementia with Lewy bodies in mild cognitive impairment

Kejal Kantarci et al. Neurology. .

Abstract

Objective: To predict the risk of probable dementia with Lewy bodies (DLB) competing with Alzheimer disease (AD) dementia by hippocampal volume (HV) in patients with mild cognitive impairment (MCI) with impairments in amnestic or nonamnestic cognitive domains.

Methods: Patients with MCI (n = 160) from the Mayo Clinic Alzheimer's Disease Research Center, who participated in an MRI study at baseline from 2005 to 2014, were followed with approximately annual clinical evaluations. HVs were analyzed from 3T MRIs using FreeSurfer (5.3). Hippocampal atrophy was determined from the most normal 10th percentile of the measurement distributions in a separate cohort of clinically diagnosed patients with AD dementia. The subdistribution hazard ratios for progression to probable DLB and AD dementia were estimated by taking into account the competing risks.

Results: During a median (range) follow-up of 2.0 (0.7-8.1) years, 20 (13%) patients with MCI progressed to probable DLB, and 61 (38%) progressed to AD dementia. The estimated subdistribution hazard ratio (95% confidence interval) for normal HV relative to hippocampal atrophy for progression to AD dementia was 0.56 (0.34-0.91; p = 0.02) after taking into account the competing risks. The estimated hazard ratio for normal HV relative to hippocampal atrophy for progression to probable DLB was 4.22 (1.42-12.6; p = 0.01) after adjusting for age and after including the MCI subtype in the model.

Conclusions: Preserved hippocampal volumes are associated with increased risk of probable DLB competing with AD dementia in patients with MCI. Preservation of HV may support prodromal DLB over AD, particularly in patients with MCI with nonamnestic features.

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Figures

Figure 1
Figure 1. Hippocampal volumes adjusted for total intracranial volume (HVa) in patients with mild cognitive impairment (MCI)
HVa in patients with MCI who did not progress to Alzheimer disease (AD) or dementia with Lewy bodies (DLB), patients with MCI who progressed to DLB, and patients with MCI who progressed to AD during follow-up. Dark circles indicate those labeled as having abnormal HVa for the survival analysis.
Figure 2
Figure 2. Cumulative incidences of progression to dementia with Lewy bodies (DLB) and Alzheimer disease (AD)
Cumulative incidences of progression to DLB and AD in patients with mild cognitive impairment by normal (preserved) hippocampus vs hippocampal atrophy. Hippocampal volumes are adjusted for total intracranial volume. Age is used as the timescale.
See this image and copyright information in PMC

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