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Comment
. 2016 Dec;21(12):e5-e6.
doi: 10.1634/theoncologist.2016-0286. Epub 2016 Nov 2.

In Reply

Giovanni Brandi  1 , Marzia Deserti  2   3 , Francesco Vasuri  4 , Andrea Farioli  5 , Alessio Degiovanni  4 , Andrea Palloni  2 , Giorgio Frega  2 , Maria A Barbera  2 , Stefania de Lorenzo  2 , Ingrid Garajova  2 , Mariacristina Di Marco  2 , Antonio D Pinna  6 , Matteo Cescon  6 , Alessandro Cucchetti  6 , Giorgio Ercolani  6 , Antonietta D'Errico-Grigioni  4 , Maria A Pantaleo  2 , Guido Biasco  2   7 , Simona Tavolari  2   3
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In Reply

Giovanni Brandi et al. Oncologist. 2016 Dec.

Abstract

Brandi et al. clarify data about the localization of human equilibrative nucleoside transporter 1 in cancer patients receiving gemcitabine-based chemotherapy. They discuss methodology, differences between antibodies, and recommendations for further study.

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Figures

Figure 1.
Figure 1.
DFS of 71 CC patients who received adjuvant gemcitabine chemotherapy after surgical resection, stratified according to membrane hENT-1 immunoreactivity (positive and negative) and cytoplasmic hENT-1 staining intensity (negative, low, or high). (A): Positive membrane hENT-1 staining. (B): Negative membrane hENT-1 staining. Abbreviations: CC, cholangiocarcinoma; DFS, disease-free survival; hENT-1, human equilibrative nucleoside transporter 1; IQR, interquartile range; NR, not reached.
See this image and copyright information in PMC

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References

    1. Meijer LL, Puik JR, Peters GJ, et al. hENT-1 expression and localization predict outcome after adjuvant gemcitabine in resected cholangiocarcinoma patients. The Oncologist. 2016;21:e4. - PMC - PubMed
    1. Brandi G, Deserti M, Vasuri F, et al. Membrane localization of human equilibrative nucleoside transporter 1 in tumor cells may predict response to adjuvant gemcitabine in resected cholangiocarcinoma patients. The Oncologist. 2016;21:600–607. - PMC - PubMed
    1. Nivillac NM, Bacani J, Coe IR. The life cycle of human equilibrative nucleoside transporter 1: From ER export to degradation. Exp Cell Res. 2011;317:1567–1579. - PubMed

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