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Review
. 2016:2016:7242478.
doi: 10.1155/2016/7242478. Epub 2016 Oct 11.

Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis

Huajun Wang  1 , Yanmei Cheng  2 , Decheng Shao  3 , Junyuan Chen  1 , Yuan Sang  1 , Tao Gui  1 , Simin Luo  1 , Jieruo Li  1 , Chao Chen  4 , Yongguang Ye  5 , Yong Yang  6 , Yikai Li  4 , Zhengang Zha  1
Affiliations
Review

Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis

Huajun Wang et al. Evid Based Complement Alternat Med. 2016.

Abstract

Background. Studies revealed that metabolic factors might contribute substantially to osteoarthritis (OA) pathogenesis. There has been an increasing interest to understand the relationship between knee OA and the metabolic syndrome (MetS). The purpose of this study was to explore the association between metabolic syndrome and knee osteoarthritis using meta-analysis. Methods. Databases, including PUBMED, EMBASE, and the Cochrane Library, were searched to get relevant studies. Data were extracted separately by two authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Results. The meta-analysis was finished with 8 studies with a total of 3202 cases and 20968 controls finally retrieved from the database search. The crude pooled OR is 2.24 (95% CI = 1.38-3.64). Although there was significant heterogeneity among these studies, which was largely accounted for by a single study, the increase in risk was still significant after exclusion of that study. The pooled adjusted OR remained significant with pooled adjusted OR 1.05 (95% CI = 1.03-1.07, p < 0.00001). No publication bias was found in the present meta-analysis. Conclusions. The synthesis of available evidence supports that metabolic syndrome increases the risk for knee osteoarthritis, even after adjustment for many risk factors.

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Figures

Figure 1
Figure 1
Flow chart of studies selection.
Figure 2
Figure 2
Forest plot of MetS exposure and KOA risk.
Figure 3
Figure 3
Publication bias evaluated by funnel plots in studies of MetS exposure and KOA risk.
Figure 4
Figure 4
Galbraith plot of ORs of OA.
Figure 5
Figure 5
Forest plot of MetS exposure and KOA risk with risk factors adjusted.
Figure 6
Figure 6
Publication bias evaluated by funnel plots in studies of MetS exposure and KOA risk with risk factors adjusted.
See this image and copyright information in PMC

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