Metabolomics in pancreatic cancer biomarkers research

doi:10.1007/s12032-016-0853-6

Review

. 2016 Dec;33(12):133.

doi: 10.1007/s12032-016-0853-6. Epub 2016 Nov 2.

Metabolomics in pancreatic cancer biomarkers research

Jaroslav Tumas¹, Kotryna Kvederaviciute², Marius Petrulionis¹, Benediktas Kurlinkus³, Arnas Rimkus⁴, Greta Sakalauskaite⁴, Jonas Cicenas^{5

6

7}, Audrius Sileikis^{8

9}

Affiliations

¹ Center of Abdominal Surgery, Vilnius University Hospital, Santariskiu Klinikos Santariskiu str. 2, 08661, Vilnius, Lithuania.
² Institute of Biotechnology, Vilnius University, Saulėtekio ave. 7, 01222, Vilnius, Lithuania.
³ Center of Hepatology, Gastroenterology and Dietology, Vilnius University Hospital, Santariskiu Klinikos Santariskiu str. 2, 08661, Vilnius, Lithuania.
⁴ Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
⁵ Vetsuisse Faculty, Institute of Animal Pathology, University of Bern, 3012, Bern, Switzerland. j.cicenas@mapkinases.eu.
⁶ MAP Kinase Resource, Bioinformatics, Melchiorstrasse 9, 3027, Bern, Switzerland. j.cicenas@mapkinases.eu.
⁷ Proteomics Centre, Institute of Biochemistry, Vilnius University, 08662, Vilnius, Lithuania. j.cicenas@mapkinases.eu.
⁸ Center of Abdominal Surgery, Vilnius University Hospital, Santariskiu Klinikos Santariskiu str. 2, 08661, Vilnius, Lithuania. audrius.sileikis@santa.lt.
⁹ Center of Hepatology, Gastroenterology and Dietology, Vilnius University Hospital, Santariskiu Klinikos Santariskiu str. 2, 08661, Vilnius, Lithuania. audrius.sileikis@santa.lt.

PMID: 27807722
DOI: 10.1007/s12032-016-0853-6

Review

Metabolomics in pancreatic cancer biomarkers research

Jaroslav Tumas et al. Med Oncol. 2016 Dec.

. 2016 Dec;33(12):133.

doi: 10.1007/s12032-016-0853-6. Epub 2016 Nov 2.

Authors

Jaroslav Tumas¹, Kotryna Kvederaviciute², Marius Petrulionis¹, Benediktas Kurlinkus³, Arnas Rimkus⁴, Greta Sakalauskaite⁴, Jonas Cicenas^{5

6

7}, Audrius Sileikis^{8

9}

Affiliations

¹ Center of Abdominal Surgery, Vilnius University Hospital, Santariskiu Klinikos Santariskiu str. 2, 08661, Vilnius, Lithuania.
² Institute of Biotechnology, Vilnius University, Saulėtekio ave. 7, 01222, Vilnius, Lithuania.
³ Center of Hepatology, Gastroenterology and Dietology, Vilnius University Hospital, Santariskiu Klinikos Santariskiu str. 2, 08661, Vilnius, Lithuania.
⁴ Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
⁵ Vetsuisse Faculty, Institute of Animal Pathology, University of Bern, 3012, Bern, Switzerland. j.cicenas@mapkinases.eu.
⁶ MAP Kinase Resource, Bioinformatics, Melchiorstrasse 9, 3027, Bern, Switzerland. j.cicenas@mapkinases.eu.
⁷ Proteomics Centre, Institute of Biochemistry, Vilnius University, 08662, Vilnius, Lithuania. j.cicenas@mapkinases.eu.
⁸ Center of Abdominal Surgery, Vilnius University Hospital, Santariskiu Klinikos Santariskiu str. 2, 08661, Vilnius, Lithuania. audrius.sileikis@santa.lt.
⁹ Center of Hepatology, Gastroenterology and Dietology, Vilnius University Hospital, Santariskiu Klinikos Santariskiu str. 2, 08661, Vilnius, Lithuania. audrius.sileikis@santa.lt.

PMID: 27807722
DOI: 10.1007/s12032-016-0853-6

Abstract

Pancreatic cancer is one of the worst prognoses of all malignancies. More than 40,000 deaths a year from this disease are observed in European Union alone. The only possibly curative treatment of pancreatic cancer is surgery, yet only 15-20% of patients have operable disease and even patients, which go through surgery and adjuvant chemotherapy, survival is less than 30%. The sensitive and specific biomarkers which could be used for the advance of early diagnostics are needed and constantly researched. Metabolomics is a technology which analyzes the concentrations of low-molecular-weight metabolites (the metabolome) has lately effectively developed due to the improvements in analytical technology. Metabolome analysis can be a one of the useful approaches for the biomarker discovery and disease diagnosis. Here we discuss recent discoveries in the field of pancreatic cancer metabolomics as well as the most promising biomarkers for diagnostics, prognosis and prediction.

Keywords: Biomarkers; Metabolome; Metabolomics; Pancreatic cancer.

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[1] Biomark Med. 2016 Jun;10 (6):577-86 - PubMed

[2] Biomark Med. 2016 Jun;10 (6):577-86 - PubMed

[3] Rinsho Byori. 2015 Apr;63(4):450-6 - PubMed

[4] Rinsho Byori. 2015 Apr;63(4):450-6 - PubMed

[5] J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 25;813(1-2):59-65 - PubMed

[6] J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 25;813(1-2):59-65 - PubMed

[7] PLoS One. 2014 Nov 20;9(11):e113259 - PubMed

[8] PLoS One. 2014 Nov 20;9(11):e113259 - PubMed

[9] Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):140-7 - PubMed

[10] Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):140-7 - PubMed

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Metabolomics in pancreatic cancer biomarkers research

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Metabolomics in pancreatic cancer biomarkers research

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