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Editorial
. 2016 Nov 8;68(19):2097-2098.
doi: 10.1016/j.jacc.2016.09.911.

Modeling and Genome-Editing Brugada Syndrome in a Dish

Affiliations
Editorial

Modeling and Genome-Editing Brugada Syndrome in a Dish

Hee Cheol Cho. J Am Coll Cardiol. .
No abstract available

Keywords: Brugada syndrome; arrhythmias; disease model; genome editing; induced pluripotent stem cells.

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References

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    1. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. a multicenter report. J Am Coll Cardiol 1992;20:1391–6. - PubMed
    1. Sander JD, Joung JK. CRISPR-Cas systems for editing, regulating and targeting genomes. Nat Biotechnol 2014;32:347–55. - PMC - PubMed
    1. Liang P, Sallam K, Wu H, et al. Patient-specific and genome-edited induced pluripotent stem cell-derived cardiomyocytes elucidate single-cell phenotype of brugada syndrome. J Am Coll Cardiol 2016;68:2086–96. - PMC - PubMed
    1. Calloe K, Refaat MM, Grubb S, et al. Characterization and mechanisms of action of novel NaV1.5 channel mutations associated with Brugada syndrome. Circ Arrhythm Electrophysiol 2013;6:177–84. - PubMed

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