Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Nov 3;6(11):e013086.
doi: 10.1136/bmjopen-2016-013086.

Health-related quality of life after pulmonary embolism: a cross-sectional study

Mazdak Tavoly  1   2   3 , Kristin Kornelia Utne  1   2 , Lars-Petter Jelsness-Jørgensen  1   4 , Hilde Skuterud Wik  5 , Frederikus A Klok  6 , Per Morten Sandset  2   4 , Waleed Ghanima  1   2
Affiliations

Health-related quality of life after pulmonary embolism: a cross-sectional study

Mazdak Tavoly et al. BMJ Open. .

Abstract

Objectives: The psychological effects of acute pulmonary embolism (PE) have scarcely been studied. The aims of this study were to evaluate health-related quality of life (HRQoL) in patients with a history of PE compared with that of the general population and buddy controls, and to explore factors that may predict impaired HRQoL.

Design: Cross-sectional.

Setting: Haematology and thrombosis unit in Fredrikstad, Norway.

Participants: 213 consecutive patients treated for PE were identified from hospital registries. Eligible patients were scheduled for a single study visit, including a functional capacity test (6 min walking test). HRQoL was assessed using the EuroQol 5D dimensions 3-level (EQ-5D-3L) questionnaire, of which the results were compared with Danish population norms and age-matched and sex-matched buddy controls. The buddy controls were recruited by asking every patient to hand over the EQ-5D questionnaire to 2 age-matched and sex-matched friends or relatives. Multivariable regression analyses were used to examine possible determinants of reduced HRQoL.

Results: Mean age was 61 years (SD 15), 117 (55%) were males, and median time since diagnosis was 3.8 years (range 0.3-9.5). Mean EuroQol visual analogue scale (EQ VAS) was 67 in PE as compared with 81 in the general population (p<0.005) and corresponding EQ-5D index values were 0.80 and 0.86 (p<0.005). Patients reported more problems in all 5 EQ-5D compared with both the buddy controls and the general population, p<0.05. Shorter 6 min walking distance (β=0.09, p<0.005) and patient-reported dyspnoea (β=11.27, p<0.005) were independent predictors of lower EQ VAS scores.

Conclusions: Our findings show that patients with a history of PE have impaired HRQoL when compared with the general population and buddy controls. Reduced functional capacity and persistent dyspnoea were the main predictors of this impairment.

Keywords: cross-sectional; exercise tolerance; pulmonary embolism; quality of life.

PubMed Disclaimer

Conflict of interest statement

WG reports grants and lecture honoraria from Bayer, Novartis and Roche and lecture and advisory board honoraria from Pfizer, Bayer and from Boehringer Ingelheim. LPJ-J reports unrestricted grants from Ferring pharmaceuticals and Tillots pharma, and personal fees from Abbvie.

Figures

Figure 1
Figure 1
Study flow chart. 6MWT, 6 min walking test; EQ-5D-3L, EuroQol five-dimension three-level; HRQoL, health related quality of life; PE, pulmonary embolism; QoL, quality of life.
Figure 2
Figure 2
Proportion of patients, Danish population and buddy controls reporting problems stratified by EQ-5D dimensions. EQ-5D, EuroQol five-dimension.
See this image and copyright information in PMC

References

    1. Kahn SR. The post-thrombotic syndrome: progress and pitfalls. Br J Haematol 2006;134:357–65. 10.1111/j.1365-2141.2006.06200.x - DOI - PubMed
    1. Fedullo PF, Auger WR, Kerr KM et al. . Chronic thromboembolic pulmonary hypertension. N Engl J Med 2001;345:1465–72. 10.1056/NEJMra010902 - DOI - PubMed
    1. Pengo V, Lensing AWA, Prins MH et al. . Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. N Engl J Med 2004;350:2257–64. 10.1056/NEJMoa032274 - DOI - PubMed
    1. Klok FA, Tijmensen JE, Haeck MLA et al. . Persistent dyspnea complaints at long-term follow-up after an episode of acute pulmonary embolism: results of a questionnaire. Eur J Intern Med 2008;19:625–9. 10.1016/j.ejim.2008.02.006 - DOI - PubMed
    1. Klok FA, Cohn DM, Middeldorp S et al. . Quality of life after pulmonary embolism: validation of the PEmb-QoL Questionnaire. J Thromb Haemost 2010;8:523–32. 10.1111/j.1538-7836.2009.03726.x - DOI - PubMed