Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Dec;32(4):507-508.
doi: 10.1007/s12288-016-0690-y. Epub 2016 Jun 4.

Knuckle Pigmentation: A Clue to Systemic Illness

Affiliations

Knuckle Pigmentation: A Clue to Systemic Illness

Arjun Lakshman et al. Indian J Hematol Blood Transfus. 2016 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Compliance with Ethical Standards On behalf of all the co-authors (listed above) I would like to state that this work has not been submitted currently elsewhere in any other journal. Conflict of interest No conflict of interest by any of the authors. Ethical Approval Conducted study did not involve any animal requiring approval for the same. Informed Consent Informed Consent was obtained from all individual participants included in the study.

Figures

Fig. 1
Fig. 1
Clinical photograph showing hyperpigmentation of skin over the knuckles of fingers of both hands
Fig. 2
Fig. 2
Photomicrograph of peripheral blood film, showing anisopoikilocytosis with macroovalocytes and a hypersegmented neutrophil in the centre. (magnification ×400)

References

    1. Hvas AM, Nexo E. Diagnosis and treatment of vitamin B12 deficiency—an update. Haematologica. 2006;91(11):1506–1512. - PubMed
    1. Kannan R, Ng MJM. Cutaneous lesions and vitamin B12 deficiency. Can Fam Physician. 2008;54(4):529–532. - PMC - PubMed
    1. Baker SJ, Ignatius M, Johnson S, Vaish SK. Pigmentation and vitamin-B12 deficiency. BMJ. 1963;2(5366):1205. doi: 10.1136/bmj.2.5366.1205-b. - DOI - PMC - PubMed
    1. Aaron S, Kumar S, Vijayan J, Jacob J, Alexander M, Gnanamuthu C (2005) Clinical and laboratory features and response to treatment in patients presenting with vitamin B12 deficiency-related neurological syndromes. Neurol India 53(1):55–58; discussion 59 - PubMed
    1. Agrawala R, Sahoo S, Choudhury A, Mohanty B, Baliarsinha A. Pigmentation in vitamin B12 deficiency masquerading Addison’s pigmentation: a rare presentation. Indian J Endocrinol Metab. 2013;17(7):254. doi: 10.4103/2230-8210.119591. - DOI - PMC - PubMed

LinkOut - more resources