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Review
. 2017 Apr 11;23(21):4950-4961.
doi: 10.1002/chem.201604564. Epub 2017 Jan 12.

Recent Progress Toward the Synthesis of Trifluoromethyl- and Difluoromethyl-Substituted Cyclopropanes

Maxence Bos  1 , Thomas Poisson  1 , Xavier Pannecoucke  1 , André B Charette  2 , Philippe Jubault  1
Affiliations
Review

Recent Progress Toward the Synthesis of Trifluoromethyl- and Difluoromethyl-Substituted Cyclopropanes

Maxence Bos et al. Chemistry. .

Abstract

This Minireview describes recent advances toward the synthesis of trifluoromethyl- and difluoromethyl-substituted cyclopropanes. Synthetic methodologies using [2+1] cycloaddition, ring-contraction, and ring-closure cyclopropanations since 2010 are reported.

Keywords: difluoromethyl; fluorine; substituted cyclopropanes; synthetic methods; trifluoromethyl.

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